丙氨酸转移酶和天门冬氨酸转移酶与γ-谷氨酰转移酶在肝脏疾病患者中的表达及临床价值  

Expression and clinical value of alanine transaminase,aspartate transaminase andγ-glutamyl transferase in patients with liver diseases

作　　者：尹莹莹 郭豆花 陈敏 YIN Yingying;GUO Douhua;CHEN Min(Department of Clinical Laboratory,Ji'an First People's Hospital,Jiangxi,Ji'an,343000,China)

机构地区：[1]吉安市第一人民医院检验科,江西吉安343000

出　　处：《当代医学》2024年第34期134-137,共4页Contemporary Medicine

基　　金：吉安市指导性科技计划项目(20233-043860)。

摘　　要：目的分析丙氨酸转移酶(alanine transaminase,ALT)、天门冬氨酸转移酶(aspartate transaminase,AST)与γ-谷氨酰转移酶(γ-glutamyl transferase,GGT)在肝脏疾病患者中的表达及其临床价值。方法选取2020年1月至2022年12月吉安市第一人民医院收治的50例肝脏疾病患者作为研究组,另选取同期于本院体检的56名健康者作为对照组,两组均进行血清ALT、AST与GGT水平检测。比较两组及研究组中不同肝脏疾病患者ALT、AST、GGT水平及其阳性检出率。结果研究组血清ALT、AST、GGT水平及阳性检出率均高于对照组,差异有统计学意义(P<0.05)。肝癌、肝硬化患者血清ALT水平均低于慢性病毒性肝炎患者,血清AST、GGT水平均高于慢性病毒性肝炎患者,且肝癌患者血清ALT、AST、GGT水平均高于肝硬化患者,差异有统计学意义(P<0.05)。肝癌、肝硬化患者ALT阳性检出率均低于慢性病毒性肝炎患者,差异有统计学意义(P<0.017),而肝癌与肝硬化患者比较差异无统计学意义;不同肝脏疾病患者血清AST、GGT阳性检出率比较差异均无统计学意义。结论ALT、AST与GGT可作为临床诊疗肝脏疾病的参考指标,具有较高的临床价值。Objective To analyze the expression and clinical value of alanine transaminase(ALT),aspartate transaminase(AST)andγ-glutamyl transferase(GGT)in patients with liver diseases.Methods 50 patients with liver diseases admitted to Ji'an First People's Hospital from January 2020 to December 2022 were selected as the study group,and another 56 healthy subjects who underwent physical examination in our hospital at the same time were selected as the control group,the serum ALT,AST and GGT levels were detected in the two groups.The levels of ALT,AST,GGT and their positive detection rates were compared between the two groups and patients with different liver diseases in the study group.Results The levels and positive detection rates of serum ALT,AST and GGT in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum ALT levels in patients with liver cancer and cirrhosis were lower than those in patients with chronic viral hepatitis,serum AST and GGT levels were higher than those in patients with chronic viral hepatitis,and serum ALT,AST and GGT levels in patients with liver cancer were higher than those in patients with cirrhosis,the differences were statistically significant(P<0.017).The positive detection rate of ALT in patients with liver cancer and cirrhosis was lower than that in patients with chronic viral hepatitis,and the differences were statistically significant(P<0.05),but there was no statistically significant difference between patients with liver cancer and cirrhosis;there were no significant difference in the positive detection rates of AST and GGT in patients with different liver diseases.Conclusion ALT,AST and GGT can be used as reference indexes for clinical diagnosis and treatment of liver diseases,and have high clinical value.

关 键 词：丙氨酸转移酶 天门冬氨酸转移酶 Γ-谷氨酰转移酶 肝脏疾病 

分 类 号：R73[医药卫生—肿瘤]