Design and performance of double-layered artificial chordae  

作　　者：Tingchao Zhang Yichen Dou Yang Li Rifang Luo Li Yang Weiwei Zhang Yunbing Wang Xingdong Zhang 

机构地区：[1]National Engineering Research Center for Biomaterials and College of Biomedical Engineering,Sichuan University,Chengdu,610065,China [2]Hangzhou Valgen Medtech Co,Ltd,Hangzhou,310052,China

出　　处：《Regenerative Biomaterials》2025年第1期113-125,共13页再生生物材料(英文版)

基　　金：supported by National Key Research and Development Program 2022YFC2409100;Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences[CIFMS,(no.2021-I2M-5-013)];111 Project[The Program of Introducing Talents of Discipline to Universities(no.B16033)].

摘　　要：Surgical repair with artificial chordae replacement has emerged asa standard treatment for mitral regurgitation. Expanded polytetrafluoroethylene (ePTFE) sutures are commonly employed asartificial chordae;however, they have certain limitations, such aspotential long-term rupture and undesired material/tissueresponse. This study introduces a novel approach to artificialchordae design, termed the New Artificial Chordae (NAC), whichincorporates a double-layered structure. The NAC comprises amulti-strand braided core composed of ultra-high molecularweight polyethylene (UHMWPE) fibers as the inner core, and anouter tube made of hydrophobic porous ePTFE. Compared totraditional ePTFE sutures, NAC exhibits increased flexibility,enhanced tensile strength, longer elongation and improved fatigue resistance. Moreover, NAC exhibits a more hydrophobic surface,which contributes to enhanced hemocompatibility. The study also includes in vivo investigations conducted on animal models to evaluate the biocompatibility and functional efficacy of the artificial chordae. These experiments demonstrate the enhanced durability andbiocompatibility of the NAC, characterized by improved mechanical strength, minimal tissue response and reduced thrombus formation.These findings suggest the potential application of NAC as a prosthetic chordae replacement, offering promising prospects to address thelimitations associated with current artificial chordae materials and providing novel ideas and approaches for the development of sustainable and biocompatible regenerative biomaterials.

关 键 词：artificial chordae double-layered artificial chordae EPTFE UHMWPE ANTITHROMBOTIC enhanced fatigue resistance 

分 类 号：TG1[金属学及工艺—金属学]