髓系白血病患者贫血程度与疾病进展的相关性分析  

Correlation between anemia degree and disease progression in patients with myeloid leukemia

作　　者：周雪芳 王敏芳[1] 许惠丽[1] 刘冰 张晓丽[1] 张娟[2] ZHOU Xue-fang;WANG Min-fang;XU Hui-li;LIU Bing;ZHANG Xiao-li;ZHANG Juan(Department of Hematology and Lymphoma,the First People's Hospital of Pingdingshan,Pingdingshan,Henan 450000,China;School of Medicine,Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]平顶山市第一人民医院血液淋巴瘤科,河南平顶山467000 [2]河南中医药大学医学院,郑州450000

出　　处：《医药论坛杂志》2025年第2期143-147,共5页Journal of Medical Forum

基　　金：国家自然科学基金(81303096)。

摘　　要：目的 探究髓系白血病进展期患者贫血程度与疾病进展的相关性,优化患者治疗方案,改善生存率。方法 选取2019年1月至2024年1月期间于平顶山市第一人民医院接受治疗的髓系白血病患者进行研究。根据纳入、排除标准选取其中150例作为研究对象,根据患者病情进展情况分为进展组(48例)和未进展组(102例)。统计两组患者的临床资料,logistic回归分析髓系白血病患者疾病进展的影响因素,Pearson线性分析髓系白血病患者贫血程度与疾病进展的关系。结果 本研究共纳入进展组48例,无进展组102例。进展组红细胞(red blood cell,RBC)、血小板(platelet,PLT)、平均红细胞体积(mean corpuscular volume,MCV)、可溶性转铁蛋白受体(soluble transferrin receptor,sTfR)、白细胞介素-6(interleukin-6,IL-6)、C-反应蛋白(C-reactive protein,CRP)均明显低于无进展组,同时贫血4级患者明显高于无进展组(P<0.05)。Logistic多因素回归分析显示,贫血程度、RBC、PLT、sTfR、IL-6、CRP是髓系白血病患者疾病进展发生的独立影响因素(P<0.05)。采用Pearson分析贫血程度、RBC、PLT、MCV、sTfR、IL-6和CRP与患者疾病进展的关系,发现贫血程度与疾病进展呈正相关关系(r=0.211,P=0.009),RBC、PLT、sTfR、IL-6、CRP与疾病进展呈负相关关系(r=-0.357、-0.630、-0.380、-0.722、-0.823,P均<0.001)。结论 贫血程度、RBC、PLT、sTfR、IL-6、CRP对髓系白血病患者疾病进展均具有一定的影响作用,同时,贫血程度与疾病进展呈现一定的正相关关系,临床可对患者上述指标进行监测进而制定个性化的治疗方案。Objective To explore the correlation between the degree of anemia and disease progression in patients with advanced myeloid leukemia,optimize the treatment plan for patients,and improve their survival rate.Methods The patients with myeloid leukemia who received treatment in the First People's Hospital of Pingdingshan from January 2019 to January 2024 were studied.According to the inclusion and exclusion criteria,150 patients were selected as research objects,and were divided into a progressive group(48 cases) and a non-progressive group(102 cases) according to the progression of the disease.The clinical data of the two groups were analyzed,the factors affecting the progression of myeloid leukemia were analyzed by logistic regression,and the relationship between the degree of anemia and the progression of myeloid leukemia was analyzed by Pearson linear correlation.Results A total of 48 cases were included in the progressive group and 102 cases in the non-progressive group.Red blood cell(RBC),platelet(PLT),mean corpuscular volume(MCV),soluble transferrin receptor(sTfR),interleukin-6(IL-6)and C-reactive protein(CRP) in the progressive group were significantly lower than those in the non-progressive group,while those in grade 4 anemia patients were significantly higher than those in the non-progressive group(P<0.05).Logistic multivariate regression analysis showed that anemia degree,RBC,PLT,MVC,sTfR,IL-6 and CRP were independent influencing factors in myeloid leukemia patients with disease progression(P<0.05).Pearson was used to analyze the relationship between anemia degree,RBC,PLT,IL-6,CRP and disease progression,and found that anemia degree was positively correlated with disease progression(r=0.211,P=0.009).RBC,PLT,sTfR,IL-6 and CRP were negatively correlated with disease progression(r=-0.357,-0.630,-0.380,-0.722,-0.823,all P<0.001).Conclusion Anemia degree,RBC,PLT,sTfR,IL-6 and CRP all have a certain effect on the disease progression of patients with myeloid leukemia,and the degree of anemia is positively correla

关 键 词：髓系白血病 贫血 进展 相关性 

分 类 号：R733.7[医药卫生—肿瘤]