不同根管封闭剂充填对前牙慢性根尖周炎患者的疗效及对龈沟液炎性因子水平的影响  

Effect of different root canal sealants on therapeutic effect and levels of inflammatory factors in gingival crevicular fluid of patients with chronic apical periodontitis of anterior teeth

作　　者：王月亭 金丽佳 李伟 WANG Yue-ting;JIN Li-jia;LI Wei(Department of Stomatology,Xuchang Central Hospital,Xuchang,Henan 461000,China)

机构地区：[1]许昌市中心医院口腔科,河南许昌461000

出　　处：《医药论坛杂志》2025年第2期158-162,共5页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20230929)。

摘　　要：目的 探究不同根管封闭剂充填方式在前牙慢性根尖周炎患者治疗中的效果,以及对患者龈沟液炎性因子水平产生的影响。方法 随机选取2021年1月—2022年12月许昌市中心医院收治的72例前牙慢性根尖周炎患者为研究对象,根据根管充填封闭剂的不同进行分组,分为A组(iRoot SP),B组(AH Plus),每组36例。A组采用iRoot SP根管封闭剂,B组采用AH Plus根管封闭剂。采用视觉模拟评分(visual analog scale,VAS)评估患者疼痛程度,X线摄片评估根管充填质量,根尖周指数(periapical index,PAI)评估患者恢复效果,炎性因子检测采用酶联免疫吸附分析法(enzyme linked immunosorbent assay,ELISA)。比较A组和B组的VAS评分、根管充填质量(恰填率)、PAI评分、疗效、龈沟液炎性因子[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)、白细胞介素-1β(interleukin-1 β,IL-1β)、白细胞介素-24(interleukin-24,IL-24)]水平和咀嚼功能[咀嚼效率(masticatory efficiency,ME)、咬合力(bite force,BF)]水平。结果 A组和B组治疗前的VAS评分、PAI评分、TNF-α、CRP、IL-6、IL-1β、IL-24水平、ME、BF水平差异无统计学意义(P>0.05);治疗后A组和B组的VAS评分、PAI评分、TNF-α、CRP、IL-6、IL-1β、IL-24水平下降,且A组较B组更低,差异有统计学意义(P<0.05);治疗后A组和B组的ME、BF水平上升,且A组较B组更高,差异有统计学意义(P<0.05);A组的治疗总有效率(100.00%)和根管充填质量(恰填率)(94.44%)均高于B组(83.33%)和(76.47%),差异有统计学意义(P<0.05)。结论 分别使用iRoot SP根管封闭剂和AH Plus根管封闭剂治疗前牙慢性根尖周炎患者,iRoot SP根管封闭剂更能提高患者的根管充填质量、改善咀嚼功能,减轻炎症反应和疼痛程度,改善病情和提高治疗效果。Objective To explore the effects of different root canal sealer filling methods in the treatment of patients with chronic apical periodontitis of anterior teeth,as well as the impact on the levels of inflammatory factors in the gingival crevicular fluid of these patients.Methods From January 2021 to December 2022,totally 72 patients with chronic apical periodontitis of anterior teeth admitted to Xuchang Central Hospital were selected as the study subjects.They were divided into group A(iRoot SP) and group B(AH Plus) based on different sealants used for root canal filling,with 36 cases in each group.Group A used iRoot SP root canal sealant,while Group B used AH Plus root canal sealant.Visual analog scale(VAS) was used to evaluate the degree of pain in patients,X-ray was used to evaluate the quality of root canal filling,periapical index(PAI) was used to evaluate the recovery effect of patients,and enzyme linked immunosorbent assay(ELISA) was used to detect inflammatory factors.Compare the VAS score,root canal filling quality(filling rate),PAI score,therapeutic effect,gingival crevicular fluid inflammatory factors[tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),interleukin-1 β(IL-1 β),interleukin-24(IL-24)]levels and chewing function[masticatory efficiency(ME),bite force(BF)]levels between Group A and Group B.Results There was no significant difference in VAS score,PAI score,TNF-α,CRP,IL-6,IL-1 β,IL-24 level,ME,BF level between Group A and Group B before treatment(P>0.05);after treatment,the VAS score,PAI score,TNF-α,CRP,IL-6,IL-1 β,and IL-24 levels in Group A and Group B decreased,and Group A were lower than those in the Group B,and the differences were statistically significant(P<0.05);after treatment,the levels of ME and BF in Group A and Group B increased,and Group A were higher than those in the Group B,and the differences were statistically significant(P<0.05);the total effective rate of treatment in Group A(100.00%) and the quality of root canal filling(94.44%) were higher

关 键 词：AH Plus根管封闭剂 iRoot SP根管封闭剂 慢性根尖周炎 疗效 龈沟液炎性因子 

分 类 号：R781.341[医药卫生—口腔医学]