调强放疗联合同步化疗对宫颈癌患者生存率与局部控制及远处复发转移的影响分析  

Effects of IMRT combined with synchronous chemotherapy on survival rate and local control and distant recurrence and metastasis of cervical cancer patients

作　　者：曾庆范 张帆[1] 王颖拓 ZENG Qing-fan;ZHANG Fan;WANG Ying-tuo(Department of Radiotherapy,Nanyang Central Hospital,Nanyang,Henan 473000)

机构地区：[1]南阳市中心医院放疗科,河南南阳473000

出　　处：《医药论坛杂志》2025年第2期175-179,184,共6页Journal of Medical Forum

摘　　要：目的 探讨调强放疗联合同步化疗对宫颈癌患者的近期疗效、安全性、生活质量、3年生存率、局部控制率以及远处复发转移的影响,评估其综合治疗效果。方法 本研究纳入2017年3月至2019年3月在南阳市中心医院收治的92例中晚期宫颈癌患者,采用随机数字表法将患者分为对照组与观察组(n=46)。对照组患者采用常规放疗联合同步化疗进行治疗,观察组患者采用IMRT联合同步化疗进行治疗,分析两组患者的近期疗效、不良反应发生情况、生活质量评分、生存率、局部控制率及远处复发转移率。结果 观察组患者的疾病控制率为93.48%,高于对照组患者的疾病控制率(78.26%),且差异有统计学意义(P<0.05)。观察组患者骨髓抑制(58.70%)、放射性直肠炎(26.09%)及放射性膀胱炎(19.57%)的发生率均低于对照组患者(78.26%、58.70%、47.83%),且差异均有统计学意义(P<0.05)。治疗后观察组生活质量高于对照组,差异有统计学意义(P<0.001)。Kaplan-Meier生存曲线分析可见观察组治疗后3年生存率(78.26%)高于对照组(58.70%),差异有统计学意义(P<0.05)。观察组患者治疗1年后及3年后局部控制率均高于对照组患者,但差异无统计学意义(P>0.05)。观察组患者治疗3年后远处复发转移率低于对照组患者,但差异无统计学意义(P>0.05)。结论 IMRT联合同步化疗对中晚期宫颈癌患者有较好的疗效,能够提高患者生活质量,且不良反应较少,值得推广。Objective To investigate the short-term efficacy,safety,quality of life,3-years survival rate,local control rate,and impact on distant recurrence and metastasis of concurrent chemoradiotherapy in cervical cancer patients and to evaluate its overall therapeutic effect.Methods A total of 92 patients with advanced cervical cancer admitted to Nanyang Central Hospital from March 2017 to March 2019 were enrolled in this study,and were randomly divided into control group and observation group according to the random number table method(n=46).The patients in the control group were treated with conventional radiotherapy combined with synchronous chemotherapy,and the patients in the observation group were treated with IMRT combined with synchronous chemotherapy.The short-term efficacy,occurrence of adverse reactions,quality of life score,survival rate,local control rate,and distant recurrence and metastasis rate of the two groups were analyzed.Results The disease control rate of observation group was 93.48%,higher than that of control group(78.26%),and the difference was statistically significant(P<0.05).The incidences of myelosuppression(58.70%),radiation proctitis(26.09%) and radiation cystitis(19.57%) in observation group were lower than that in control group(78.26%,58.70%,47.83%),and the differences were statistically significant(P<0.05).After treatment,the quality of life in observation group was higher than that in control group,and the difference was ststistically significant(P<0.001).Kaplan-Meier survival curve analysis showed that the 3-years survival rate of observation group(78.26%) was higher than that of control group(58.70%),and the difference was ststistically significant(P<0.05).The local control rate of observation group was higher than that of control group 1 or 3 years after treatment,but the difference was not statistically significant(P>0.05).The distant recurrence and metastasis rate of observation group was lower than that of control group after 3 years of treatment,but the difference was not statist

关 键 词：宫颈癌 调强放疗 同步化疗 疗效 安全性 生活质量 

分 类 号：R737.33[医药卫生—肿瘤]