血清Ki-67和M-CSF及IL-10在宫颈上皮内瘤变与宫颈癌鉴别诊断中的作用  

Role of serum Ki-67 and M-CSF and IL-10 in differential diagnosis of cervical intraepithelial neoplasia and cervical cancer

作　　者：翟韶 王晓燕 李玉玮 周瑞民 ZHAI Shao;WANG Xiao-yan;LI Yu-wei;ZHOU Rui-min(Department of Laboratory Medicine,the Third Peoples Hospital of Puyang,Henan 457000,China;Department of Gynecology,the Third Peoples Hospital of Puyang,Henan 457000,China)

机构地区：[1]濮阳市第三人民医院检验科,河南濮阳457000 [2]濮阳市第三人民医院妇科,河南濮阳457000

出　　处：《医药论坛杂志》2025年第2期216-220,F0003,共6页Journal of Medical Forum

摘　　要：目的 研究血清Ki-67、巨噬细胞集落刺激因子(macrophage colony stimulating factor,M-CSF)、白介素-10(interleukin-10,IL-10)联合检测对宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)与宫颈癌中的诊断价值。方法 选取濮阳市第三人民医院于2020年7月—2023年12月治疗的48例宫颈癌以及72例宫颈癌上皮内瘤变患者,检测患者的血清Ki-67、M-CSF、IL-10水平,使用多因素分析、受试者工作特征(receiver operating characteristic,ROC)曲线分析血清指标对颈上皮内瘤变与宫颈癌鉴别诊断的价值。结果 两组患者年龄、产次、体重指数(body mass index,BMI)、孕次以及出现接触性出血的例数无统计学差异(P>0.05),CIN组患者分泌物异常例数明显高于宫颈癌组,数据差异有统计学意义(P<0.05);CIN组患者的M-CSF、IL-10水平以及Ki-67表达阳性例数均明显低于宫颈癌组,差异有统计学意义(P<0.05);血清M-CSF、IL-10以及Ki-67水平偏高均是影响宫颈癌发生的独立危险因素(P<0.05);ROC分析结果表明,M-CSF、IL-10及Ki-67单独诊断宫颈癌的曲线下面积(area under the curve,AUC)为0.799、0.856和0.812,灵敏度分别为72.50%、82.50%、70.00%,特异度分别为80.00%、80.00%、82.50%,联合诊断AUC提升至0.928,灵敏度和特异度分别为92.50%、82.50%。结论 血清Ki-67、M-CSF、IL-10指标可以作为对宫颈上皮内瘤变与宫颈癌患者诊断预测的指标,联合诊断的价值较高。Objective To study the diagnostic value of combined detection of serum Ki-67,macrophage colony stimulating factor(M-CSF),and interleukin-10(IL-10)in cervical intraepithelial neoplasia(ClN)and cervical cancer.Methods Selected 72 cases of cervical intraepithelial neoplasia(CIN) cervical cancer and 48 cases of cervical cancer that treated in the Third People's Hospital of Puyang from July 2020 to December 2023,to detect Ki-67,M-CSF,IL-10 in serum,using a multi-factor analysis of the receiver operating characteristic(ROC) curve to determine the value of endothemia in the cervix and cervical cancer.Results Lack of statistical significance of differences in age,body mass index(BMI),postpartum,pregnancy,and contact bleeding(P>0.05),the abnormal number of excretions in patients with CIN was much higher than that in cervical cancer groups,and the difference was statistically significant(P<0.05);M-CSF,IL-10,as well as Ki-67,which expressed a positive expression,were well below the level of cervical cancer,and the differences in the data were statistically significant(P<0.05);elevated serum levels of M-CSF,IL-10,and Ki-67 were independent risk factors affecting the development of cervical cancer(P<0.05);ROC analysis showed that the area under the curve(AUC),in which M-CSF,IL-10,and Ki-67 diagnosed cervical cancer separately were 0.799,0.856 and 0.812,respectively;sensitivity were 72.50,82.50 and 70.00 %,respectively;exclusivity were 80.00%,80.00% and 82.50%,respectively;the overall diagnosis of AUC rose to 0.928,sensitivity and specificity were 92.50,and 82.50,respectively.Conclusion Serum indicators Ki-67,M-CSF,IL-10 may be used as an indicator for the diagnosis of patients with epithelial-cervical tumors and cervical cancer,and the combined diagnosis is more valuable.

关 键 词：宫颈上皮内瘤变 宫颈癌 诊断 

分 类 号：R737.33[医药卫生—肿瘤]