睑板腺功能障碍患者眼表疾病指数量表评分与临床体征的相关性分析  

Correlation between ocular surface disease index score and clinical signs in patients with meibomian gland dysfunction

作　　者：魏树瑾[1,2] 赵金荣 张远龙 褚文娟 沈丹[1,2] 黄薇伊 田璐[2,3] WEI Shujin;ZHAO Jinrong;ZHANG Yuanlong;CHU Wenjuan;SHEN Dan;HUANG Weiyi;TIAN Lu(Outpatient Operating Room,Tianjin Eye Hospital,Tianjin 300020,China;不详)

机构地区：[1]天津市眼科医院门诊手术室,天津300020 [2]天津市眼科学与视觉科学重点实验室,天津300020 [3]天津市眼科医院角膜病科,天津300020 [4]天津市眼科医院中西医结合科,天津300020

出　　处：《山东医药》2025年第3期111-115,共5页Shandong Medical Journal

基　　金：天津市卫生健康委员会中医中西医结合科研课题资助项目(2023208);河北省中医药管理局科研计划项目资助(T2025030);天津市医学重点学科(专科)建设项目资助(TJYXZDXK-016A)。

摘　　要：目的分析睑板腺功能障碍(MGD)患者主观症状眼表疾病指数量表评分(OSDI)与临床体征的关系。方法选择MGD患者42例(84只眼),均进行OSDI问卷调查(包含眼部症状、视觉功能和环境触发因素3个小节),同时检查临床体征[睑板腺分泌物排出能力评分、睑板腺分泌物性状评分、睑板腺缺失情况评分、泪膜破裂时间(BUT)、角膜荧光素染色(FL)评分],分析OSDI及其各小节评分与临床体征相关指标之间的相关性。结果MGD患者(84只眼)的OSDI评分(35.86±10.48)分,其中眼部症状评分6.00(4.00,8.00)分、视觉功能评分4.00(2.00,6.00)分、环境触发因素评分4.00(3.00,6.00)分;睑板腺分泌物排出能力评分(11.17±2.75)分,睑板腺分泌物性状评分(2.57±1.10)分,睑板腺缺失情况评分(2.52±0.94)分,BUT(6.62±4.31)s,FL评分0.00(0.00,2.00)分。MGD患者(84只眼)OSDI评分与睑板腺分泌物排出能力评分、FL评分均呈正相关关系(r分别为0.278、0.305,P均<0.05),与BUT呈负相关关系(r=–0.237,P<0.05);眼部症状评分与睑板腺分泌物排出能力评分、睑板腺分泌物性状评分、睑板腺缺失情况评分、BUT、FL评分均无明显相关性(P均>0.05);视觉功能评分与睑板腺分泌物排出能力评分、FL评分均呈正相关关系(r分别为0.217、0.230,P均<0.05);环境触发因素评分与睑板腺分泌物排出能力评分呈正相关关系(r=0.228,P<0.05),与BUT呈负相关关系(r=–0.253,P<0.05)。结论在MGD的诊断与治疗过程中,结合OSDI评分及各小节评分等主观症状与睑板腺功能、泪膜稳定性及角膜健康状况等客观临床体征综合评估,可以更准确地反映病情严重程度,有利于早期诊断及治疗。Objective To explore the relationships between the Ocular Surface Disease Index(OSDI)score for subjective symptom and clinical signs in patients with meibomian gland dysfunction(MGD).Methods Forty-two patients(84 eyes)with MGD were selected.All patients underwent the OSDI questionnaire survey(including three sections:ocular symptoms,visual function,and environmental triggering factors),and meanwhile,we examined the clinical signs[meibomian gland secretion excretion capability score,meibomian gland secretion quality score,meibomian gland loss score,tear film breakup time(BUT)measurement,corneal fluorescein staining(FL)score],and analyzed the correlation among these indicators.Results Among 84 eyes of MGD patients,the score of OSDI questionnaire was(35.86±10.48),the score of ocular symptom was[6.00(4.00,8.00)],the score of visual function was[4.00(2.00,6.00)],the score of environmental triggering factor was[4.00(3.00,6.00)],the score of meibomian gland secretion excretion capability was 11.17±2.75,the score of meibomian gland secretion quality was 2.57±1.10,and the score of meibomian gland loss was 2.52±0.94,BUT was(6.62±4.31)s,the score of FL was[0.00(0.00,2.00)].The OSDI score of MGD patients(84 eyes)was positively correlated with meibomian gland secretion excretion capability score and FL score(r=0.278 and 0.305,both P<0.05);OSDI score was negatively correlated with BUT(r=-0.237,P<0.05).The ocular symptom score was not correlated with meibomian gland secretion excretion capability score,meibomian gland secretion quality score,meibomian gland loss score,BUT or FL score(all P>0.05).Visual function score was positively correlated with meibomian gland secretion excretion capability score and FL score(r=0.217 and 0.230,both P<0.05).Environmental triggering factor score was positively correlated with meibomian gland secretion excretion capability score(r=0.228,P<0.05),and was negatively correlated with BUT(r=-0.253,P<0.05).Conclusions In the process of diagnosis and treatment of MGD,combined with the total OSDI s

关 键 词：睑板腺功能障碍 眼表疾病指数量表 泪膜破裂时间 角膜 睑板腺 

分 类 号：R771.3[医药卫生—眼科]