血清SIRT1、IL-32和IL-37水平与急性胰腺炎患者病情严重程度及预后的关联  

Association of serum SIRT1,IL-32 and IL-37 levels with severity and prognosis in patients with acute pancreatitis

作　　者：周瑶军 宋自昌 李晓静 王矩伟 王胤 ZHOU Yao-jun;SONG Zi-chang;LI Xiao-jing;WANG Ju-Wei;WANG Yin(Department of Critical Care Medicine,Puyang Oilfield General Hospital,Puyang,Henan 457001,China;Haozhou People's Hospital,Bozhou 236800,Anhui Province,China)

机构地区：[1]濮阳油田总医院重症医学科,河南濮阳457001 [2]豪州市人民医院,安徽亳州236800

出　　处：《医药论坛杂志》2025年第1期44-48,共5页Journal of Medical Forum

基　　金：亳州市卫生健康委员会重点课题(bzwj20234003)。

摘　　要：目的观察急性胰腺炎(acute pancreatitis,AP)患者血清沉默信息调节因子1(serum silence-information regulator 1,SIRT1)、白介素-32(interleukin-32,IL-32)和白介素-37(interleukin-37,IL-37)表达水平及其与预后的相关性。方法纳入2021年3月至2024年3月于濮阳油田总医院就诊的134例AP患者,经纳入与排除标准筛选,同时剔除不愿参与研究和资料不全者,最终纳入120例患者作为研究对象。根据患病严重程度将患者分为轻症急性胰腺炎(mild acute pancreatitis,MAP)组42例,中重症急性胰腺炎(moderate severe acute pancreatitis,MSAP)组40例,重症急性胰腺炎(severe acute pancreatitis,SAP)组38例,另选取120例于濮阳油田总医院进行体检的健康体检者作为对照。采用酶联免疫吸附法检测受试者血清SIRT1、IL-32和IL-37水平,采用Pearson相关检验分析三者水平与急性胰腺炎严重程度的相关性,受试者工作特征曲线(receiver operating characteristic,ROC曲线)用于评估AP患者血清SIRT1、IL-32、IL-37和APACHEⅡ评分对预后的预测价值。结果血清SIRT1和IL-37水平在对照组、MAP组、MSAP组和SAP组中依次降低,而IL-32和APACHEⅡ评分在对照组、MAP组、MSAP组和SAP组中依次升高,差异有统计学意义(P<0.001);血清SIRT1和IL-37水平与患者APACHEⅡ评分呈负相关,而IL-32水平与患者APACHEⅡ评分呈正相关,差异有统计学意义(P<0.001);血清SIRT1和IL-37水平在预后不良组患者血清中低于预后良好组,而IL-32和APACHEⅡ评分在预后不良组患者血清中水平高于预后良好组,差异有统计学意义(P<0.001);ROC曲线分析结果显示,血清SIRT1、IL-32、IL-37、APACHEⅡ评分预测AP预后不良的曲线下面积分别为0.846、0.905、0.814和0.762,四种指标联合检测,曲线下面积为0.933。结论血清SIRT1、IL-32和IL-37水平在AP患者血清中升高且与病情严重程度相关,动态监测SIRT1、IL-32和IL-37对于评估AP患者病情严重程度和预后具有重要意义�Objective To observe the expression levels of serum silence-information regulator 1(SIRT1),interleukin-32(IL-32)and interleukin-37(IL-37)in patients with acute pancreatitis(AP)and their correlation with prognosis.Methods A retrospective analysis was performed on 134 patients with AP in the Puyang Oilfield General Hospital from March 2021 to March 2024.After inclusion and exclusion criteria screening,and excluding those who were unwilling to participate in the study and incomplete data,120 patients were finally included as research objects.Based on the disease's seriousness,the patients were categorized into groups:mild acute pancreatitis(MAP)with 42 cases,moderate severe acute pancreatitis(MSAP)with 40 cases,severe acute pancreatitis(SAP)with 38 cases.Additionally,120 healthy individuals who had undergone physical examinations at the same hospital were chosen as the control group.Serum SIRT1,IL-32 and IL-37 levels were detected by enzyme-linked immunosorbent assay,and the correlation between the levels and the severity of AP was analyzed using Pearson correlation test.Receiver operating characteristic(ROC)curve was used to assess the prognostic significance of serum levels of SIRT1,IL-32,and IL-37 in patients with acute pancreatitis.Results Serum SIRT1 and IL-37 levels were decreased in control group,MAP group,MSAP group and SAP group,while IL-32 and APACHEⅡscores were increased in control group,MAP group,MSAP group and SAP group,the difference was statistically significant(P<0.001).Serum SIRT1 and IL-37 levels were negatively correlated with APACHEⅡscore,while IL-32 levels were positively correlated with APACHEⅡscore(P<0.001).The levels of Serum SIRT1 and IL-37 were reduced in the poor prognosis group compared to the good prognosis group,whereas IL-32 levels and APACHEⅡscores were elevated in the poor prognosis group in contrast to the good prognosis group,the difference was statistically significant(P<0.001).The findings from the analysis of the ROC curve demonstrated the area under the curve of serum S

关 键 词：急性胰腺炎 血清沉默信息调节因子1 白介素-32 白介素-37 病情严重程度 预后 

分 类 号：R576[医药卫生—消化系统]