微RNA在周围神经损伤后轴突再生中的作用的文献计量学研究  

Bibliometric study on the application of microRNAs for axonal regeneration after peripheral nerve injury

作　　者：库提鲁克·守克尔 艾克拜尔江·艾赛提 沙拉依丁·艾尔西丁 艾克热木江·木合热木[1] KUTILUKE·Shoukeer;AIKEBAIERJIANG·Aisaiti;SHALAYIDING·Aierxiding;AIKEREMUJIANG·Muheremu(Department of Orthopedics,Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002)

机构地区：[1]新疆医科大学第六附属医院骨科,乌鲁木齐830002

出　　处：《神经解剖学杂志》2025年第1期80-88,共9页Chinese Journal of Neuroanatomy

基　　金：国家自然科学基金(82260252,8237152292,81860235,82074452);新疆维吾尔自治区自然科学基金资助项目面上项目(2022D01C330,2022D01C331);新疆维吾尔自治区研究生实践创新项目(XJ2024G186);省部共建中亚高发病成因与防治国家重点实验室开放课题面上项目(SKL-HIDC-2022-16);“天池英才”引进计划青年博士项目。

摘　　要：目的:周围神经损伤(PNI)是最常见的一种临床疾病。本研究通过文献计量学方法分析微RNA(miRNA)在周围神经后轴突再生中的治疗作用的当今研究热点和未来发展趋势,从而为后来相关研究提供可靠的参考。方法:应用Web of Science数据库,通过关键词TS=microRNA OR TS=miRNA AND TS=peripheral nerve injury OR TS=microRNA OR TS=miRNA AND TS=axonal regeneration筛检采集从2009年到2024年间发表的相关文章数据。并用可视化分析软件CiteSpace,从文献的作者、所属国家、关键词、爆发词和机构等方面进行评估。结果:从Web of Science数据库中共检索到301篇文献,通过剔除和筛选最终符合研究的文献有288篇。本研究所用的288篇文章共有1513名作者,他们分别来自34个国家,358个机构的1513名作者发表在148篇期刊上。引用了来自2038期刊的13941篇文献。另外本研究列出了文献年发表量、国家分布、发文量前5的作者、被引次数最多的5篇文章和发文量前十的机构,其中中国是发文量最多的国家,但在文章质量上跟欧美地区有着显著的差距。对机构的分析发现,国内机构在该领域的研究中占比最多,相互之间的合作密切,与国外机构缺乏合作。研究引用次数最多的文章是Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor被引用了34次。发文量最多的机构是南通大学31篇。结论:虽然miRNA在周围神经损伤后轴突再生中的治疗作用研究起步较晚,论文数量相对较少,但有着极大的发展潜力。miRNA作为当今最热门的话题,它在神经炎症、神经细胞修复再生、神经保护和功能恢复等领域的作用机制已经成为当前的研究热点。随着对该领域科研研究的投入,将会有更多高质量的文章发表在国内外优秀期刊上,使得周围神经损伤的治疗迎来新的纪元。Objective:Peripheral nerve injury(PNI)is the most common clinical condition.In this study,the current hotspot and future trends of the therapeutic role of microRNA(miRNA)in posterior axon regeneration were evaluated,through bibliometric analysis of peripheral nerves,to provide a reliable reference for later related studies.Methods:Published data from 2009 to 2024 were collected from the Web of Science database by key words TS=microRNA OR TS=miRNA AND TS=peripheral nerve injury OR TS=microRNA OR TS=miRNA AND TS=axonal regeneration screening.The visualization analysis software CiteSpace was used to evaluate the author,country,keywords,outbreak words,institutions,etc.Results:A total of 301 documents were retrieved from the Web of Science database,and 288 documents finally fit the study post eliminating and screening.The 288 articles used in this study have a total of 1513 authors from 34 countries,and 1513 authors from 358 institutions published in 148 journals,citing 13941 articles from 2038 journals.In addition,this study lists the top 5 authors of the annual publication,national distribution,5 articles with the most cited times and the top ten institutions of articles.Moreover,among them,China is the country with the largest number of articles,but there is still a significant gap in the quality of articles when compared with European and American regions.The analysis of institutions found that domestic institutions account for the largest proportion of the research in this field,with close mutual cooperation,but lack of cooperation with foreign institutions.The most cited article in research is“Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor”which was cited 34 times.The institution with the largest publication volume is 31 articles from Nantong University.Conclusion:Although the research on therapeutic role of tiny RNA in axon regeneration after peripheral nerve injury started late,the number of papers is relatively small,but it has great potential.As the most popular

关 键 词：周围神经损伤 微RNA 轴突再生 文献计量学 周围神经再生 可视化分析 

分 类 号：R745[医药卫生—神经病学与精神病学] G353.1[医药卫生—临床医学]