Tree shrew as a new animal model for musculoskeletal disorders and aging  

作　　者：Xiaocui Wei Honghao Li Jingyang Qiu Jianlin Jiao Xiongtian Guo Gaosheng Yin Ping Yang Yi Han Qiongzhi Zhao Hao Zeng Zhi Rao Xuefei Gao Kai Li Pinglin Lai Sheng Zhang Chengliang Yang Di Lu Xiaochun Bai 

机构地区：[1]State Key Laboratory of Organ Failure Research,Department of Cell Biology,School of Basic Medical Sciences,Southern Medical University,Guangzhou,510515,China [2]Department of Histology and Embryology,School of Basic Medical Sciences,Southern Medical University,Guangzhou,510515,China [3]Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases,The Third Affiliated Hospital of Southern Medical University,Guangzhou,510630,China [4]Yunnan Key Laboratory of Stem Cell and Regenerative Medicine,School of Rehabilitation,Kunming Medical University,Kunming,650500,China [5]Department of Physiology,School of Basic Medical Sciences,Southern Medical University,Guangzhou,510515,China [6]Guangxi Key Laboratory for Biomedical Material Research,Department of Orthopedics,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise,533000,China

出　　处：《Bone Research》2025年第1期91-103,共13页骨研究(英文版)

基　　金：National Natural Science Foundation of China(Grant Nos.92268204,32160209,82160175);Yunling Scholar Project of Yunnan Revitalization Talent Support Program,the Foundation of Expert Workstation of Bai Xiaochun(YSZJGZZ-2020040);Applied Basic Research Foundation of Yunnan Province(Grant Nos.202001AY070001-014,202201AY070001-032)。

摘　　要：Intervertebral disc degeneration(IDD),osteoarthritis(OA),and osteoporosis(OP)are common musculoskeletal disorders(MSDs)with similar age-related risk factors,representing the leading causes of disability.However,successful therapeutic development and translation have been hampered by the lack of clinically-relevant animal models.In this study,we investigated the potential suitability of the tree shrew,a small mammal with a close genetic relationship to primates,as a new animal model for MSDs.Age-related spontaneous IDD in parallel with a gradual disappearance of notochordal cells were commonly observed in tree shrews upon skeletal maturity with no sex differences,while age-related osteoporotic changes including bone loss in the metaphyses were primarily presented in aged females,similar to observations in humans.Moreover,in the osteochondral defect model,tree shrew cartilage exhibited behavior similar to that of humans,characterized by a more restricted self-healing capacity compared to the rapid spontaneous healing of joint surfaces observed in rats.The induced OA model in tree shrews was highly efficient and reproducible,characterized by gradual deterioration of articular cartilage,recapitulating the human OA phenotype to some degree.Surgery-induced IDD models were successfully established in tree shrews,in which the lumbar spine instability model developed slow progressive disc degeneration with more similarity to the clinical state,whereas the needle puncture model led to the rapid development of IDD with more severe symptoms.Taken together,our findings pave the way for the development of the tree shrew as a new animal model for the study of MSDs and aging.

关 键 词：HEALING SURGERY DEGENERATION 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]