放射性口腔黏膜炎防治药物研究进展  

Research progress on drugs for the prevention and treatment of radiotherapy-induced oral mucositis

作　　者：王佳敏 安韡 陈文革 WANG Jia-min;AN Wei;CHEN Wen-ge(Shanxi Medical University School and Hospital of Stomatology,Taiyuan 030001;Department of Oral Surgery,Shanxi Provincial People's Hospital,Shanxi Medical University(Shanxi Provincial Oral Health Prevention and Control Technology Innovation Center),Taiyuan 030012,Shanxi Province,China)

机构地区：[1]山西医科大学口腔医学院,山西太原030001 [2]山西医科大学附属山西省人民医院口腔外科(山西省口腔健康防控技术创新中心),山西太原030012

出　　处：《中国口腔颌面外科杂志》2025年第2期196-201,共6页China Journal of Oral and Maxillofacial Surgery

基　　金：山西省自然科学研究项目(202103021224374)。

摘　　要：放射性口腔黏膜炎是头颈癌患者接受放射治疗最常见的并发症之一,会引发黏膜溃疡、剧烈疼痛、进食和吞咽困难等功能障碍,致使治疗中断,影响疗效。目前认为,放射性口腔黏膜炎是一个多靶点的复杂动态过程,针对这些靶点进行药物治疗,可以预防和控制黏膜炎的发生、发展。本文针对黏膜炎的不同靶点,包括DNA损伤、氧化应激通路、口腔微生物群、上皮增殖、镇痛管理,对放射性黏膜炎的防治药物研究进展进行综述,为未来研究和临床防治放射性口腔黏膜炎提供参考与理论依据。Radiation oral mucositis is one of the most common complications of radiotherapy in patients with head and neck cancer.It can lead to mucosal ulceration,severe pain,eating and swallowing difficulties and other functional disorders,resulting in treatment interruption and poor curative effect.Radiation oral mucositis is currently believed to be a complex and dynamic process with multiple targets,and drug therapy targeting these targets can prevent and control the occurrence and development of mucositis.This review discussed the research progress of drugs for prevention and treatment of radiation mucositis,aiming at different targets of mucositis,including DNA damage,oxidative stress pathway,oral microbiota,epithelial proliferation,and analgesic management,which will provide references for the future research and clinical prevention and treatment of radiation oral mucositis.

关 键 词：放射治疗 头颈癌 放射性口腔黏膜炎 靶点 

分 类 号：R781.5[医药卫生—口腔医学]