基于生物钟对口腔颌面部鳞状细胞癌精准诊疗的基础研究和临床应用专家共识  

Expert consensus on the basic research and clinical application of circadian clock for the precision diagnosis and treatment of oral and maxillofacial squamous cell carcinoma

作　　者：杨凯[1] 孙沫逸 李龙江[3] 唐瞻贵[4] 郭伟[5] 任国欣[5] 张志伟[1] 唐洪[1] 张杰[6] 孙志军[7] 席庆 李春洁[3] 黄欣[9] 武和明[10] 尚伟[11] 孟箭[12] 李吉辰[13] 马洪 朱桂全[3] 李一[3] 李尧旭 何海涛 张富贵[17] 章杰[18] 赵丹 孙德平 吕晓强[1] 陈丹[1] 张福军[1] 陈睿[1] 李雅冬[1] 张劲松[1] 付小娟 项立[21] 李受益 尹仕琳 YANG Kai;SUN Moyi;LI Longjiang;TANG Zhangui;GUO Wei;REN Guoxin;ZHANG Zhiwei;TANG Hong;ZHANG Jie;SUN Zhijun;XI Qing;LI Chunjie;HUANG Xin;WU Heming;SHANG Wei;MENG Jian;LI Jichen;MA Hong;ZHU Guiquan;LI Yi;LI Yaoxu;HE Haitao;ZHANG Fugui;ZHANG Jie;ZHAO Dan;SUN Deping;LV Xiaoqiang;CHEN Dan;ZHANG Fujun;CHEN Rui;LI Yadong;ZHANG Jinsong;FU Xiaojuan;XIANG Li;LI Shouyi;YIN Shilin(Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Chongqing Medical University,400016,China;State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Key Laboratory of Stomatology,Department of Oral and Maxillofacial Surgery,School of Stomatology,The Fourth Military Medical University,Xi'an;Department of Head and Neck Oncology Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu;Department of Oral and Maxillofacial Surgery,Xiangya School of Stomatology,Central South University,Changsha;Department of Oromaxillofacial Head and Neck Oncology,Shanghai Ninth People's Hospital,College of Stomatology,Shanghai Jiao Tong University School of Medicine;Department of Oral and Maxillofacial Surgery,School and Hospital of Stomatology,Peking University,Beijing;Department of Oral and Maxillofacial-Head Neck Oncology Surgery,School and Hospital of Stomatology,Wuhan University;Oral Department of 1st Medical Center,Chinese PLA General Hospital,Beijing;Department of Oral and Maxillofacial-Head and Neck Oncology,Beijing Stomatological Hospital,Capital Medical University;Department of Oral and Maxillofacial Surgery,Stomatological Hospital Affiliated to Nanjing Medical University;Department of Oral and Maxillofacial Surgery,Affiliated Hospital of Qingdao University;Department of Oral and Maxillofacial Surgery,Xuzhou Central Hospital;Department of Oral and Maxillofacial Surgery,The First Affiliated Hospital of Harbin Medical University;Department of Oral and Maxillofacial Surgery,Stomatological Hospital of Guizhou Medical University,Guiyang;Department

机构地区：[1]重庆医科大学附属第一医院口腔颌面外科,400016 [2]空军军医大学口腔医院口腔颌面头颈肿瘤科 [3]四川大学华西口腔医学院头颈肿瘤外科 [4]中南大学湘雅口腔医学院口腔颌面外科 [5]上海交通大学医学院附属第九人民医院口腔医学院口腔颌面-头颈肿瘤科 [6]北京大学口腔医学院口腔颌面外科 [7]武汉大学口腔医学院口腔颌面头颈肿瘤外科 [8]中国人民解放军总医院第一医学中心口腔科 [9]首都医科大学附属北京口腔医院口腔颌面头颈肿瘤科 [10]南京医科大学附属口腔医院口腔颌面外科 [11]青岛大学附属医院口腔颌面外科 [12]徐州市中心医院口腔颌面外科 [13]哈尔滨医科大学附属第一医院口腔颌面外科 [14]贵州医科大学附属口腔医院口腔颌面外科 [15]重庆大学附属三峡医院口腔中心 [16]陆军军医大学第二附属医院(新桥医院)口腔科 [17]重庆医科大学附属口腔医院口腔颌面外科 [18]南昌大学第一附属医院口腔颌面外科 [19]西南医科大学附属口腔医院口腔颌面外科 [20]重庆医科大学附属大学城医院耳鼻咽喉头颈外科 [21]重庆医科大学附属儿童医院口腔科 [22]青岛大学附属烟台毓璜顶医院口腔科

出　　处：《实用口腔医学杂志》2025年第2期149-156,共8页Journal of Practical Stomatology

基　　金：重庆市科学技术局基础研究与前沿探索项目(编号:cstc2022ycjh-bgzxm0064);重庆英才·创新创业领军人才项目(编号:CQYC20200303128);重庆市自然科学基金(编号:cstc2018jcyjAX0208)。

摘　　要：研究表明,口腔黏膜细胞的生理稳态受到生物钟的调控,生物钟异常或紊乱与口腔鳞癌的发生发展密切相关,基于生物钟的研究将为口腔鳞癌的发生机制及治疗模式带来全新的认识。但目前的相关研究较少,人们对生物钟的理解和认识还很有限。鉴于作为医学研究第四维度的生物钟的复杂性和挑战性,我们组织相关专家在总结目前生物钟在人口腔鳞癌发生机制及精准诊疗研究成果的基础上,结合生物钟作用的科学原理和自身长期的研究经验,归纳推荐了生物钟对口腔颌面部鳞癌的发生机制及精准诊疗研究的共识意见,希望能为生物钟或昼夜节律在口腔颌面部鳞癌发生机制及精准诊疗的基础研究和临床应用中提供参考指导。Recent studies have shown that the physiological homeostasis of oral mucosal cells is regulated by the circadian clock.Disruption or dysfunction of the circadian clock is closely associated with the development of oral squamous cell carcinoma(OSCC).Research based on the circadian clock offers a novel perspective on the pathogenesis and therapeutic strategies for OSCC.However,there is currently limited research on this topic,and people generally have insufficient understanding and recognition of the circadian clock.Given the complexity and challenges of circadian clock which is the fourth dimension of medical research,we organize relevant experts based on summarizing the current research results of circadian clock in the pathogenesis and precision diagnosis and treatment of OSCC,combining the scientific principles of the circadian clock's role and their long-term research experience,then summarizes and recommends the consensus opinions for the research of circadian clock in the pathogenesis mechanism and precision diagnosis and treatment of human OSCC,with the hope of providing guidance for the basic research and clinical application of circadian clock or circadian rhythm in the pathogenesis mechanism and precision diagnosis and treatment of oral and maxillofacial squamous cell carcinoma.

关 键 词：生物钟 昼夜节律 鳞状细胞癌 口腔 颌面部 专家共识 

分 类 号：R739.8[医药卫生—肿瘤]