基于CiteSpace的阿尔茨海默病并精神行为异常治疗研究现状与热点分析  

Analysis of current status and hotspots in the treatment of Alzheimer′s disease with behavioural and psychological symptoms of dementia based on CiteSpace

作　　者：方勇涛[1] 吕继辉[2] 席蕾 黄志勇[1] 李沫[2] 李文杰[2] 时光 周燕谊 FANG Yongtao;LYU Jihui;XI Lei;HUANG Zhiyong;LI Mo;LI Wenjie;SHI Guang;ZHOU Yanyi(Department of GeriatricsⅠ,the Affiliated Panyu Central Hospital of Guangzhou Medical University,Guangzhou 511400,China;不详)

机构地区：[1]广州医科大学附属番禺中心医院老年医学科一区,广州511400 [2]北京老年医院认知障碍科,北京100095

出　　处：《中国临床保健杂志》2025年第1期43-48,共6页Chinese Journal of Clinical Healthcare

摘　　要：目的分析近20年国内外阿尔茨海默病(AD)并精神行为异常(BPSD)治疗相关领域的研究现状、研究热点及发展趋势。方法检索并收录中国国家知识基础设施(CNKI)和Web of Science(WOS)核心数据库2004年1月1日至2024年9月18日AD并BPSD治疗的相关文献,利用CiteSpace 6.2 R4软件进行数据处理和可视化分析。结果共检索纳入CNKI数据库中文文献196篇,WOS数据库英文文献103篇。中文文献发文量呈上升趋势,英文文献发文量基本稳定。发文空间分布分析显示,WOS数据库内英国发文量最多(24篇),其次为日本(13篇),我国发文量(5篇)排名第十。CNKI中有3家机构发文量居前(各3篇),其合作中心度几乎为0。关键词聚类及突现词分析示:研究热点均集中在精神类药物、胆碱酯酶抑制剂、银杏叶提取物等。国内研究者关注药物的联合治疗(精神类药物联合胆碱酯酶抑制剂),国外研究者更倾向于单药治疗的研究。可预测药物治疗仍是未来国内外AD并BPSD治疗的主要研究热点。国外研究者对AD患者生活质量、照护的关注比国内早,非药物干预、传统中医中药将是该领域的未来研究趋势。结论发文量分析显示,中国在AD并BPSD治疗方面的研究起步较晚,但近10年发文量逐渐超过国外研究者。英国是在该研究领域研究最多、与他国合作最广泛的国家。我国机构间合作微弱,跨区域间合作几乎为零,需加强国内外多中心机构合作。Objective To analyze the research status,hotspots,and development trends in the field of Alzheimer′s disease(AD)with Behavioural and Psychological symptoms of dementia(BPSD)treatment in the past 20 years,both domestically and internationally,to provide reference for future research in related fields.Methods Retrieve relevant literature on the treatment of AD with BPSD from China National Knowledge Infrastructure(CNKI)and Web of Science Core Collection(WOSCC)from January 1,2004 to September 18,2024 were collected,and CiteSpace 6.2 R4 software was used for data processing and visualization analysis.Results Date were retrieved from CNKI and WOSSC.In total,196 Chinese literature in the CNKI and 103 English literature in WOSSC were included in the analysis.The number of Chinese literature publications is on the rise,while the number of English publications remains stable.The spatial distribution analysis of publications showed that the UK has the highest number of publications in WOS(n=24),followed by Japan(n=13),and China ranks 10 th in terms of publications(n=5).CNKI conducts analysis based on institutions as nodes,with a maximum of 3 articles published and a cooperation centrality of almost 0.Keyword clustering and analysis of prominent words showed that the research hotspots at home and abroad are focused on psychiatric drugs,acetylcholinesterase inhibitors,Ginkgo biloba extract,etc.Domestic researchers tend to study combination therapy with drugs(psychiatric drugs combined with cholinesterase inhibitors),while foreign researchers tend to study monotherapy.It can be predicted that drug therapy will remain the main research hotspot for the treatment of AD with BPSD both domestically and internationally in the future.Foreign researchers had paid earlier attention to the quality of life and care of AD patients than in China.Non pharmacological interventions and traditional Chinese medicine will be the future research trends in this field.Conclusions China′s research on the treatment of AD with BPSD started relati

关 键 词：阿尔茨海默病 精神障碍 聚类分析 数据可视化 

分 类 号：R74[医药卫生—神经病学与精神病学]