急性脑梗死患者沉默信息调节因子2与认知功能障碍发生及病情程度的关系  

Relationship between SIRT2 and occurrence and disease severity of cognitive impairment in patients with acute cerebral infarction

作　　者：倪厚杰[1] 朱瑞 覃双来[3] 李新华[2] Ni Houjie;Zhu Rui;Qin Shuanglai;Li Xinhua(Department of Neurology,Wuhan No.1 Hospital,Wuhan 430022,Hubei Province,China)

机构地区：[1]武汉市第一医院神经内科,430022 [2]武汉市第一医院体检中心,430022 [3]武汉市第一医院肿瘤科,430022

出　　处：《中华老年心脑血管病杂志》2025年第4期436-439,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的分析急性脑梗死患者沉默信息调节因子2(silent information regulator 2,SIRT2)与认知功能障碍发生及病情程度的关系。方法回顾性选择2022年5月至2024年5月武汉市第一医院神经内科收治的急性脑梗死合并认知功能障碍患者150例(研究组),研究组依据认知功能障碍严重程度分为轻度组45例、中度组66例和重度组39例。另选取同期武汉市第一医院就诊的急性脑梗死未合并认知功能障碍患者125例(对照组)。采用Spearman相关性分析血清SIRT2水平与认知功能障碍及病情程度的相关性,ROC曲线分析血清SIRT2水平对认知功能障碍及病情的评估价值,并计算曲线下面积(area under curve,AUC)。结果研究组血清SIRT2水平明显高于对照组,差异有统计学意义[(20.38±5.19)mg/L vs(14.66±4.49)mg/L,P<0.05]。重度组血清SIRT2水平明显高于中度组和轻度组,中度组血清SIRT2水平明显高于轻度组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,血清SIRT2水平与认知功能障碍发生及严重程度呈正相关(r=0.510,r=0.527,P<0.01)。ROC曲线分析显示,血清SIRT2水平评估急性脑梗死患者认知功能障碍发生的AUC为0.796(95%CI:0.743~0.842),临界值为19.0 mg/L,敏感性为63.33%,特异性为84.00%;血清SIRT2水平评估急性脑梗死患者认知功能障碍严重程度的AUC为0.747(95%CI:0.655~0.824),临界值为17.2 mg/L,敏感性为75.76%,特异性为71.11%(P<0.05)。结论急性脑梗死患者血清SIRT2水平与认知功能障碍发生及病情密切相关。Objective To analyze the relationship of silent information regulator 2(SIRT2)with the occurrence and severity of cognitive impairment in patients with acute cerebral infarction(ACI).Methods Clinical data of 150 ACI patients(study group)complicated with cognitive impairment admitted in our hospital from May 2022 to May 2024 were collected and analyzed retrospectively.According to the severity of cognitive impairment,they were divided into mild(45 cases),moderate(66 cases)and severe subgroups(39 cases).Another 125 ACI patients without cognitive dysfunction admitted in our hospital during the same period were recruited and served as the control group.Spearman correlation analysis was adopted to analyze the correlation between serum SIRT2 level and cognitive impairment and disease severity.ROC curve analysis was applied to assess the value of serum SIRT2 level for cognitive impairment and its severity,and its area under the curve(AUC)was calculated.Results The serum SIRT2 level was significantly higher in the study group than the control group(20.38±5.19 mg/L vs 14.66±4.49 mg/L,P<0.05),so was in the severe subgroup than the moderate and mild subgroups,and in the moderate subgroup than the mild subgroup(P<0.05).Spearman analysis showed that serum SIRT2 level was positively correlated with the occurrence and severity of cognitive impairment(r=0.510,r=0.527,P<0.01).ROC curve analysis indicated that the AUC value of serum SIRT2 level in evaluating the occurrence of cognitive impairment was 0.796(95%CI:0.743-0.842),with a cutoff value,sensitivity and specificity of 19.0 mg/L,63.33%and 84.00%,respectively,and the AUC value was 0.747(95%CI:0.655-0.824)in assessing the severity of cognitive impairment,with a cutoff value,sensitivity and specificity of 17.2 mg/L,75.76%and 71.11%,respectively(P<0.05).Conclusion Serum SIRT2 level is closely associated with the occurrence and severity of cognitive impairment in ACI patients.

关 键 词：脑梗死 认知障碍 数据相关性 沉默信息调节因子2 

分 类 号：R74[医药卫生—神经病学与精神病学]