Research progress on the non-coding region of single-stranded positive-sense RNA(+ssRNA)viruses  

单股正链RNA(+ssRNA)病毒非编码区研究进展

作　　者：Liangrong Guo Guoyue Liu Ju Sun Dengguo Wei 郭亮荣;刘国月;孙巨;位灯国(华中农业大学农业微生物资源发掘与利用全国重点实验室,湖北武汉430070;华中农业大学交叉科学研究院湖北洪山实验室,湖北武汉430070;华中农业大学国家兽药残留基准实验室,国家兽药安全评价实验室,湖北武汉430070;中国农业科学院深圳农业基因组研究所,广东深圳518000)

机构地区：[1]National Key Laboratory of Agricultural Microbiology,College of Veterinary Medicine,Huazhong Agricultural University,Wuhan 430070,Hubei,China [2]Hubei Hongshan Laboratory,Interdisciplinary Sciences Institute,Huazhong Agricultural University,Wuhan 430070,Hubei,China [3]National Reference Laboratory of Veterinary Drug Residues(HZAU)and National Laboratory of Safety Evaluation for Veterinary Drug(HZAU),Huazhong Agricultural University,Wuhan 430070,Hubei,China [4]Agricultural Genomics Institute at Shenzhen,Chinese Academy of Agricultural Sciences(Shenzhen Branch,Guangdong Laboratory of Lingnan Modern Agriculture),Shenzhen 518000,Guangdong,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2025年第1期1-13,共13页中国药学(英文版)

基　　金：National Key Research and Development Programs of China(Grant No.2021YFD1801102);the National Natural Science Foundation of China(Grant No.22077043,32473010);the Fundamental Research Funds for the Central Universities(2662023PY005 to DW);HZAU-AGIS Cooperation Fund(SZYJY2022016 to DW);Natural Science Foundation of Hubei Province(2021CFA061 to DW);the Funding from National Key Laboratory of Agricultural Microbiology(AML2023B05 to DW)。

摘　　要：Single-stranded positive-sense RNA(+ssRNA)viruses encompass a diverse range of species and exert profound effects on human and animal health,as well as agricultural economic productivity.The 5'and 3'untranslated regions(UTRs)of these viruses play pivotal roles in regulating critical processes such as translation initiation,RNA synthesis,virus assembly,and virulence.This article provided an overview of the untranslated regions in representative species of single-stranded positive-sense RNA(+ssRNA)viruses,highlighting their potential in vaccine development research and addressing some of the challenges currently faced in this field.单股正链RNA病毒种类繁多,对人类和动物健康以及农业经济生产具有重大影响。病毒的5′和3′非翻译区(UTRs)在翻译起始与调控、RNA合成、病毒组装及毒力等方面发挥着关键作用。本文介绍了一些具有代表性的正义单链RNA病毒种类的非翻译区,并探讨了它们在疫苗研究中的前景以及一些现存问题。

关 键 词：+ssRNAvirus UTR Structure VACCINE 

分 类 号：R96[医药卫生—药理学]