二型肺泡上皮细胞增殖分化的研究进展  

Research progress on the proliferation and differentiation of typeⅡalveolar epithelial cells

作　　者：方耀威 林肯 张龙娟 许瑶 王云 赵竞秀 方佳 Fang Yaowei;Lin Ken;Zhang Longjuan;Xu Yao;Wang Yun;Zhao Jjingxiu;Fang Jia(Department of Respiratory and Critical Care,Dongguan Southeastern Central Hospital,Dongguan 523710,China)

机构地区：[1]东莞市东南部中心医院呼吸与危重症科,东莞523710

出　　处：《中华结核和呼吸杂志》2025年第3期282-286,共5页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：广东省自然科学基金(2023A1515012380)。

摘　　要：肺泡上皮细胞由二型肺泡上皮细胞(AT2)和一型肺泡上皮细胞(AT1)组成,其功能分别是维持肺内顺应性和肺内气体交换,其中AT2在个体的肺发育和肺修复过程中能增殖和分化为AT1,因此AT2一直被认为是肺中很重要的干细胞,然而AT2的增殖和分化障碍在许多肺疾病中出现,导致肺泡不能进行正常修复并严重影响患者的生活质量,现就AT2何时进行增殖和分化,以及影响其增殖和分化的相关关键干细胞和信号通路进行概述。The alveolar epithelium consists of two types of cells:alveolar epithelial typeⅡcells(AT2)and alveolar epithelial typeⅠcells(AT1),which function to maintain lung compliance and gas exchange,respectively.AT2 can proliferate and differentiate into AT1 during lung development and repair,thus AT2 have been regarded very important stem cells in lung.However,impaired proliferation and differentiation of AT2 were observed in many chronic lung diseases,preventing the proper repair of alveolar and significantly impacting the life quality of patients.This review focuses on when AT2 proliferate and differentiate,and highlights the critical signaling pathways that influence these processes.

关 键 词：肺泡上皮细胞 AT2 肺疾病 干细胞 修复过程 AT1 增殖和分化 增殖分化 

分 类 号：R73[医药卫生—肿瘤]