基于糖脂代谢探讨肠道微生物组与阿尔茨海默病的关系  

Discussing the link between gut microbiome and Alzheimer’s disease based on glucose and lipid metabolism

作　　者：王登坤 第五永长 苟于瑞[3] 熊鹏 WANG Dengkun;DI WU Yongchang;GOU Yurui;XIONG Peng(Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712077,China;Shaanxi University of Chinese Medicine,Xianyang 712046,China;Xidian Group Hospital,Xi’an 710077,China)

机构地区：[1]陕西中医药大学附属医院,陕西咸阳712077 [2]陕西中医药大学,陕西咸阳712046 [3]西电集团医院,陕西西安710077

出　　处：《陕西医学杂志》2025年第4期565-570,共6页Shaanxi Medical Journal

基　　金：国家自然科学基金资助面上项目(82074503);“陕西中医药大学神经退行性疾病中医药防治研究学科创新团队”项目(2019-QN05);陕西省“特支计划”科技创新领军人才项目(陕组通字[2018]33号)。

摘　　要：阿尔茨海默病(AD)是一种进行性记忆障碍和认知功能下降为主要表现的神经退行性疾病,目前发病机制尚不明确。已有研究表明AD可能是一种代谢性疾病,与糖脂代谢密切相关。随着微生物-肠-脑轴学说的兴起,肠道菌群与AD关系的研究逐渐成为近年来的研究热点,而肠道菌群又可显著调节机体糖脂代谢水平,故本文综述AD、糖脂代谢及肠道菌群三者之间的关系,旨在为肠道菌群经代谢途径影响AD提供理论基础,为AD发病机制的未来研究提供新的思路。Alzheimer’s disease(AD)is a neurodegenerative disease mainly manifested by memory and cognitive dysfunction,and its pathogenesis is still unclear.Studies have shown that AD may be a metabolic disease,which is closely related to glucose and lipid metabolism.With the rise of the microbe-gut-brain axis theory,gut microbiota and AD have gradually become research hotspots in recent years,and gut microbiota can significantly regulate the level of glucose and lipid metabolism in the body.Therefore,this article reviews AD,glucose and lipid metabolism and The relationship between the three gut microbiota aims to provide a theoretical basis for the influence of gut microbiota on AD through metabolic pathways,and to provide new ideas for future research on the pathogenesis of AD.

关 键 词：阿尔茨海默病 糖代谢 脂质代谢 脑代谢 代谢紊乱 肠道微生物 

分 类 号：R743[医药卫生—神经病学与精神病学]