固本抗癌方治疗乳腺癌术后化疗患者骨髓抑制临床疗效  

Clinical effect of Guben Kang’ai prescription on myelosuppression in patients with breast cancer after chemotherapy

作　　者：董文敏 秦旭辉 任伊宁 冯浩 徐曌 兴伟 DONG Wenmin;QIN Xuhui;REN Yining;FENG Hao;XU Zhao;XING Wei(Department of External Medicine,First Affiliated Hospital of Hebei University of Traditional Chinese Medicine,Shijiazhuang 050011,China;Department 2 of External Medicine,Zanhuang County Traditional Chinese Medicine Hospital,Shijiazhuang 051230,China)

机构地区：[1]河北中医药大学第一附属医院外一科,河北石家庄050011 [2]赞皇县中医院外二科,河北石家庄051230

出　　处：《陕西中医》2025年第4期486-489,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2025019)。

摘　　要：目的:观察固本抗癌方对乳腺癌术后化疗患者骨髓抑制的疗效。方法:选择80例乳腺癌术后化疗患者为研究对象,随机分为对照组及观察组各40例,对照组行常规治疗,观察组加用固本抗癌方口服,观察两组骨髓抑制情况。结果:治疗4、8周,观察组中医证候积分显著低于对照组(均P<0.05);观察组白细胞、血小板、血红蛋白水平显著高于对照组(均P<0.05);观察组发生Ⅲ度以上骨髓抑制显著低于对照组(均P<0.05);观察组粒细胞集落刺激因子(GCS-F)用量、血常规恢复正常所需时间显著低于对照组(均P<0.05);观察组生活质量评分(QOL)、卡氏评分(KPS)显著高于对照组(均P<0.05)。结论:固本抗癌方治疗乳腺癌术后化疗患者,能显著减轻临床症状,提高患者生活质量,改善血细胞异常情况,减轻骨髓抑制,减少GCS-F用量,促进血常规恢复正常。Objective:To observe the effect of Guben Kang’ai prescription on myelosuppression of postoperative chemotherapy for breast cancer.Methods:A total of 80 cases of postoperative chemotherapy for breast cancer were selected as research subjects,all the enrolled pathologies were randomly divided into 40 cases each in the control and observation groups according to the random number table method,the control group was treated routinely,and the observation group was orally administered with Guben Kang’ai prescription,and the bone marrow suppression of the two groups was observed.Results:After 4 and 8 weeks of treatment,TCM syndrome scores in the observation group were significantly lower than those in the control group(all P<0.05).The levels of leukocyte,platelet and hemoglobin in observation group were significantly higher than those in control group(all P<0.05).After treatment,the incidence of myelosuppression above Ⅲ degree in observation group was significantly lower than that in control group(all P<0.05).The dosage of granulocyte colony-stimulating factor(GCS-F)and the time required for normal blood routine in observation group were significantly lower than those in control group(all P<0.05).After treatment,the quality of life score(QOL)and KPS score in the observation group were significantly higher than those in the control group(all P<0.05).Conclusion:In the treatment of patients with breast cancer after chemotherapy,Guben Kang’ai prescription can significantly reduce clinical symptoms,improve the quality of life of patients,improve blood cell abnormalities,reduce bone marrow suppression,reduce the amount of GCS-F,and promote the normal blood routine.

关 键 词：乳腺癌 固本抗癌方 辅助化疗 骨髓抑制 免疫功能 生活质量 

分 类 号：R737.9[医药卫生—肿瘤]