肠道菌群与垂体腺瘤的孟德尔随机化研究  

Mendelian randomization study on gut microbiota and pituitary adenoma

作　　者：何庭 袁坚列 HE Ting;YUAN Jianlie(Zhejiang University School of Medicine,Hangzhou 310029,Zhejiang,China;Department of Neurosurgery,the Affiliated Jinhua Hospital of Zhejiang University School of Medicine,Jinhua 321000,Zhejiang,China)

机构地区：[1]浙江大学医学院,浙江杭州310029 [2]浙江大学医学院附属金华医院神经外科,浙江金华3210001

出　　处：《中国现代医生》2025年第9期24-28,共5页China Modern Doctor

摘　　要：目的探讨肠道菌群与垂体腺瘤(pituitary adenoma,PA)之间的因果关系。方法采用双向两样本孟德尔随机化(Mendelian randomization,MR)法,利用MiBioGen和FinnGen的全基因组关联研究(genome wide association study,GWAS)数据库中关于肠道菌群(从MiBioGen联盟获得211种)和FinnGen联盟发布的R9版PA(包括1402例垂体瘤患者和375875名对照者)的汇总统计数据,分析肠道菌群与PA的因果关系。以逆方差加权法为主要分析方法,使用多效性和异质性检验验证结果的可靠性,并进行反向MR分析,以排除反向因果关联的可能。结果瘤胃球菌UCG004属(OR=1.391,95%CI:1.004~1.932,P=0.049)、纺锤链菌属(OR=1.654,95%CI:1.101~2.494,P=0.017)和氨基酸球菌科(OR=1.994,95%CI:1.252~3.173,P=0.004)可能增加PA的发病风险。相反,瘤胃梭菌5属(OR=0.634,95%CI:0.415~0.991,P=0.043)、艾森伯格菌属(OR=0.701,95%CI:0.551~0.915,P=0.007)、负抗杆菌纲(OR=0.574,95%CI:0.362~0.895,P=0.014)和广古菌门(OR=0.784,95%CI:0.644~0.975,P=0.022)可能是PA的保护因素。敏感度分析显示不存在多效性和异质性。结论肠道菌群与PA之间的因果关系可为PA的发病因素提供新的理论依据。Objective To investigate the potential causal relationship between gut microbiota and pituitary adenoma(PA).Methods Two-sample Mendelian randomization(MR)analysis was adopted by using genome wide association study(GWAS)summary statistics from the MiBioGen consortiums(obtaining 211 gut microbiota taxa)and FinnGen consortiums R9 release data(from 1402 cases PA patients and 375875 control cases)to evaluate the causal association between gut microbiota and PA.Inverse variance weighted method was used as main analysis method,and pleiotropy and heterogeneity tests were used to verify the reliability of the results.In addition,a reverse MR analysis was performed to rule out the possibility of a reverse causal association.Results Genus Ruminococcaceae UCG004(OR=1.391,95%CI:1.004-1.932,P=0.049),Fusicatenibacter(OR=1.654,95%CI:1.101-2.494,P=0.017),and family Acidaminococcaceae(OR=1.994,95%CI:1.252-3.173,P=0.004)were found to increase the risk of PA.Conversely,the genus Ruminiclostridium 5(OR=0.634,95%CI:0.415-0.991,P=0.043),genus Eisenbergiella(OR=0.701,95%CI:0.551-0.915,P=0.007),class Negativicutes(OR=0.574,95%CI:0.362-0.895,P=0.014),and phylum Euryarchaeota(OR=0.784,95%CI:0.644-0.975,P=0.022)exhibited a negative correlation with PA.Sensitivity analyses indicated the absence of pleiotropy and heterogeneity.Conclusion The causal relationship between gut microbiota and PA may provide a new theoretical basis for the pathogenesis of PA.

关 键 词：垂体腺瘤 肠道菌群 孟德尔随机化分析 逆方差加权法 

分 类 号：R739.41[医药卫生—肿瘤]