定量脑电在阿尔茨海默病治疗中的指导意义  

The guiding significance of quantitative electroencephalography in the treatment of Alzheimer’s disease

作　　者：郁玲 YU Ling(Department of Brain Disease,Jiaxing Hospital of Traditional Chinese Medicine,Jiaxing 314001,Zhejiang,China)

机构地区：[1]嘉兴市中医医院脑病科,浙江嘉兴314001

出　　处：《中国现代医生》2025年第9期37-41,共5页China Modern Doctor

摘　　要：目的研究定量脑电参数对阿尔茨海默病(Alzheimer’s disease,AD)治疗方案调整的指导意义。方法选取2023年1月至2024年1月于嘉兴市中医医院就诊的150例AD患者作为研究组,150名健康体检者作为对照组,使用美国Nicolet公司脑电图仪检查获得定量脑电参数δ+θ与α+β功率比值[(delta+theta)/(alpha+betal)ratio,DTABR],比较对照组与研究组纳入者DTABR差异,所有AD患者均根据病情严重程度使用药物和(或)非药物治疗方案,比较不同临床疗效患者DTABR差异,分析影响AD患者治疗方案无效的危险因素及DTABR预测AD患者治疗效果的效能。结果研究组患者的DTABR高于对照组,且随着AD患者病情严重程度的增加,DTABR逐渐升高(P<0.05)。Logistic回归分析显示年龄、病程、病情严重程度、DTABR是AD治疗无效的危险因素(P<0.05)。受试者操作特征曲线分析发现DTABR预测AD患者治疗效果的敏感度、特异性高于年龄、病程、病情严重程度,且各因素联合预测AD患者治疗效果的效能最优,敏感度、特异性分别为93.50%、85.46%。治疗方案调整组总有效率显著高于治疗方案维持组(P<0.05)。结论定量脑电参数DTABR与AD患者治疗效果有一定关联,可用于治疗方案的调整,对治疗方案的调整具有指导意义。Objective To study guiding significance of quantitative electroencephalography parameters for adjusting treatment plans for Alzheimer’s disease(AD).Methods 150 AD patients who received treatment at Jiaxing Hospital of Traditional Chinese Medicine from January 2023 to January 2024 were selected as study group,and 150 healthy individuals as control group.The quantitative electroencephalography parameters of(delta+theta)/(alpha+betal)ratio(DTABR)were obtained by using Nicolet’s electroencephalography of the United States.The differences of DTABR between control group and study group were compared.All AD patients were treated with drug and/or non drug therapy according to the severity of their condition.The differences of DTABR among patients with different clinical efficacy were compared,and the risk factors affecting the ineffectiveness of AD treatment plans and the efficacy of DTABR in predicting the treatment efficacy of AD patients were analyzed.Results DTABR of study group was higher than that of control group,and it gradually increased with the severity of AD patients(P<0.05).Logistic regression analysis showed that age,disease duration,severity of illness,and DTABR were risk factors for ineffective treatment of AD(P<0.05).Receiver operating characteristic curve analysis showed that DTABR had higher sensitivity and specificity in predicting the treatment efficacy of AD patients than age,disease duration,and severity.Moreover,the combination of various factors had the best efficacy in predicting the treatment efficacy of AD patients,with sensitivity and specificity of 93.50%and 85.46%,respectively.The total effective rate of treatment adjustment group was significantly higher than that of treatment maintenance group(P<0.05).Conclusion There is a certain correlation between quantitative electroencephalography parameters DTABR and the therapeutic efficacy of AD patients,which can be used for adjusting treatment plans and has guiding significance for adjustment of treatment plans.

关 键 词：阿尔茨海默病 定量脑电参数 治疗方案 临床疗效 δ+θ与α+β功率比值 

分 类 号：R741.04[医药卫生—神经病学与精神病学]