卡马西平、托吡酯与丙戊酸钠治疗脑炎继发癫痫患者的效果比较及对生活质量的影响  

Comparison of the effect of Carbamazepine,Topiramate and Sodium Valproate in the treatment of epilepsy secondary to encephalitis and their effect on quality of life

作　　者：姚兰 邹健玲 刘金苗 孙桂芳 YAO Lan;ZOU Jianling;LIU Jinmiao;SUN Guifang(The Second Department of Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang Province,Mudanjiang 157000,China;Department of General Medicine,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang Province,Mudanjiang 157000,China;Ward of the First Department of Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang Province,Mudanjiang 157000,China;Department of Orthopedics,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang Province,Mudanjiang 157000,China)

机构地区：[1]牡丹江医科大学附属红旗医院神经内二科,黑龙江牡丹江157000 [2]牡丹江医科大学附属红旗医院全科医学科,黑龙江牡丹江157000 [3]牡丹江医科大学附属红旗医院神经内一科病区,黑龙江牡丹江157000 [4]牡丹江医科大学附属红旗医院骨科,黑龙江牡丹江157000

出　　处：《中国当代医药》2025年第7期56-59,共4页China Modern Medicine

摘　　要：目的探讨卡马西平、托吡酯与丙戊酸钠对于脑炎继发癫痫的疗效、生活质量的影响。方法选取2021年1月至2023年1月牡丹江医科大学附属红旗医院纳入的96例脑炎继发癫痫患者作为研究对象,之后按照随机数字表法分为卡马西平组(32例)、托吡酯组(32例)、丙戊酸钠组(32例)。卡马西平组采用卡马西平治疗,托吡酯组采用托吡酯治疗,丙戊酸钠组采用丙戊酸钠治疗,分析不同分组的治疗差异性。结果三组治疗后的总有效率比较,差异无统计学意义(P>0.05)。三组治疗后的生活质量评分比较,差异无统计学意义(P>0.05)。卡马西平组的不良反应总发生率高于托吡酯组,丙戊酸钠组的不良反应总发生率高于托吡酯组,差异有统计学意义(P<0.017)。结论脑炎继发癫痫患者采用卡马西平、托吡酯、丙戊酸钠治疗后,疗效无明显差异性,均有利于生活质量的好转,同时,托吡酯的用药安全性更高,具有较高的临床应用价值。Objective To investigate the effect of Carbamazepine,Topiramate and Sodium Valproate on the efficacy and quality of life of patients with encephalitis secondary epilepsy.Methods A total of 96 patients with secondary epilepsy due to encephalitis enrolled in Hongqi Hospital Affiliated to Mudanjiang Medical University from January 2021 to January 2023 were selected as the research objects,and they were divided into Carbamazepine group(32 cases),Topiramate group(32 cases)and Sodium Valproate group(32 cases)according to random number table method.Carbamazepine group was treated with Carbamazepine.Topiramate group was treated with Topiramate,Sodium Valproate group was treated with Sodium Valproate,and the difference of treatment among different groups was analyzed.Results There was no significant difference in the total effective rate among the three groups(P>0.05).There was no significant difference in the quality of life scores of the three groups after treatment(P>0.05).The total incidence of adverse reactions in Carbamazepine group was higher than that in Topiramate group,and the total incidence of adverse reactions in Sodium Valproate group was higher than that in Topiramate group,with statistical significances(P<0.017).Conclusion There is no significant difference in efficacy between Carbamazepine,Topiramate and Sodium Valproate in the treatment of patients with encephalitis secondary epilepsy,which is conducive to the improvement of quality of life.At the same time,Topiramate has higher safety and clinical application value.

关 键 词：脑炎继发癫痫 卡马西平 托吡酯 丙戊酸钠 生活质量 疗效 

分 类 号：R741[医药卫生—神经病学与精神病学]