莽草酸的生物合成研究进展  

Research progress in shikimic acid biosynthesis

作　　者：夏煌慧 崔树梅 黄建忠 XIA Huanghui;CUI Shumei;HUANG Jianzhong(Engineering Research Center of Industrial Microbiology,Ministry of Education,National and Local United Engineering Research Center of Industrial Microbiology and Fermentation Technology,College of Life Sciences,Fujian Normal University,Fuzhou,Fujian,China)

机构地区：[1]福建师范大学生命科学学院,工业微生物发酵技术国家地方联合工程研究中心,工业微生物教育部工程中心,福建福州

出　　处：《微生物学报》2025年第3期916-938,共23页Acta Microbiologica Sinica

基　　金：国家重点研发计划(2022YFD1802104)。

摘　　要：莽草酸(shikimic acid, SA)是一种重要的天然化合物,在生物体内具有抗病毒、抗血栓、镇痛、抑菌、抑制恶性肿瘤等多重功能,广泛应用于医药、化妆品、食品和农业等领域,因此被视为是极具潜力的生物分子。作为芳香族化合物的前体,莽草酸在生物体内的代谢途径中起着重要作用。传统的莽草酸生产方式主要依赖于从植物(如八角茴香)中提取或通过化学合成,这些方法不仅成本高、效率低,还对环境造成负担。随着合成生物学和代谢工程技术的不断进步,利用生物代谢工程技术生产莽草酸因其更高的可持续性和经济性,逐渐成为研究热点。本文综述了莽草酸的应用领域及其生产方法,并重点阐述了其生物合成的研究进展与优化策略。Shikimic acid(SA)is an important natural compound with many biological activities,including antiviral,antithrombotic,analgesic,antimicrobial,and anti-cancer properties.Due to its diverse applications in medicine,cosmetics,food,and agriculture,SA is considered a highly promising biomolecule.As a precursor of aromatic compounds,SA plays a crucial role in various metabolic pathways within organisms.Traditional methods for producing SA mainly rely on plant extraction(such as star anise)or chemical synthesis.However,these approaches face challenges such a high costs,low efficiency,and environmental concerns.With the ongoing advancements in synthetic biology and metabolic engineering,the production of SA through metabolic engineering has emerged as a focal point of research,offering a more sustainable and cost-effective alternative.This paper reviews the applications and production methods of SA,with a particular emphasis on recent progress and optimization strategies in its biosynthesis.

关 键 词：莽草酸途径 莽草酸 生物合成 生产策略 文献信息学 

分 类 号：TQ921[轻工技术与工程—发酵工程] Q939.9[生物学—微生物学]