CsgD对沙门氏菌生物膜形成的调控作用及其影响因素的研究进展  

Research progress in the mechanism and influencing factors of CsgD regulating the biofilm formation of Salmonella

作　　者：黄颖 彭玉倩 王琪 邱少富 向莹 HUANG Ying;PENG Yuqian;WANG Qi;QIU Shaofu;XIANG Ying(College of Public Health,Zhengzhou University,Zhengzhou,Henan,China;The Chinese PLA Center for Disease Control and Prevention,Beijing,China)

机构地区：[1]郑州大学公共卫生学院,河南郑州 [2]解放军疾病预防控制中心,北京

出　　处：《微生物学报》2025年第3期956-967,共12页Acta Microbiologica Sinica

基　　金：国家自然科学基金(82202538,82173580)。

摘　　要：CsgD作为沙门氏菌生物膜形成的核心调控蛋白,通过调控生物膜的关键组成成分——纤维素和卷曲菌毛的表达,进而影响生物膜的形成。近年来,科学界在剖析沙门氏菌CsgD蛋白的调控网络及其复杂影响因素方面取得了较大进展。本文聚焦于CsgD在沙门氏菌生物膜形成过程中的调控功能,系统梳理了环境因素如何影响CsgD的功能表达,并全面分析了多种调控因子对CsgD的多层次调控作用,旨在加深对沙门氏菌生物膜形成机制及其调控网络的理解,并为后续研究提供可能的方向。CsgD,a core regulatory protein for the biofilm formation of Salmonella,exerts its function by regulating the expression of key components(curli and cellulose)of the biofilm.In recent years,significant progress has been achieved in analyzing the regulatory network of Salmonella CsgD protein and its complex influencing factors.Focusing on the regulatory function of CsgD in the biofilm formation of Salmonella,this paper systematically introduces how environmental factors affect the CsgD expression and comprehensively analyzes the multi-level regulatory effects of various regulatory factors on CsgD,aiming to enrich our understanding about the mechanism and regulatory network of the biofilm formation of Salmonella and provide possible research directions.

关 键 词：生物膜 沙门氏菌 CsgD 环境因素 调控因子 

分 类 号：R378[医药卫生—病原生物学]