普瑞巴林联合卡马西平治疗三叉神经痛的效果及对患者氧化应激反应和血清疼痛介质水平的影响  

Therapeutic effect of pregabalin combined with carbamazepine on trigeminal neuralgia and its influence on oxidative stress and serum pain mediators levels

作　　者：常琪 杨帅 Chang Qi;Yang Shuai(Liaocheng People’s Hospital,Liaocheng 252000,China)

机构地区：[1]聊城市人民医院,聊城252000

出　　处：《中国实用医刊》2025年第1期92-95,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨普瑞巴林联合卡马西平治疗三叉神经痛(TN)的效果及对患者氧化应激反应和血清疼痛介质水平的影响。方法队列研究。抽取2022年5月至2024年4月聊城市人民医院收治的TN患者70例,按随机数字表法分为对照组和观察组,每组35例。对照组单用卡马西平治疗,观察组加用普瑞巴林治疗。比较两组氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)、超氧化物歧化酶(SOD)]、血清疼痛介质[P物质(SP)、神经肽Y(NPY)、5-羟色胺(5-HT)]、临床疗效及不良反应发生率。结果治疗4周后,两组GSH-Px、SOD均较治疗前升高,MDA较治疗前下降,且观察组GSH-Px、SOD高于对照组,MDA低于对照组(P<0.05)。治疗4周后,两组SP、NPY均较治疗前降低,5-HT较治疗前升高,且观察组SP、NPY低于对照组,5-HT高于对照组(P<0.05)。观察组临床总有效率(94.29%,33/35)高于对照组(77.14%,27/35),P<0.05。两组治疗期间未见明显不良反应。结论普瑞巴林联合卡马西平治疗TN能够有效调节患者氧化应激指标及血清疼痛介质水平,减轻疼痛症状,安全有效。ObjectiveTo investigate the effects of combination therapy with pregabalin and carbamazepine on trigeminal neuralgia(TN),and to analyze its influence on oxidative stress and levels of serum pain mediators.MethodsSeventy patients with TN admitted to Liaocheng People’s Hospital from May 2022 to April 2024 were selected for the cohort study.And they were divided into the control group and the observation group using a random number table method,with 35 cases in each group.The control group was given carbamazepine alone,and the observation group was given pregabalin combined with carbamazepine.The oxidative stress indexes including glutathione peroxidase(GSH-Px),malondialdehyde(MDA)and superoxide dismutase(SOD),serum pain mediators including substance P(SP),neuropeptide Y(NPY)and 5-hydroxytryptamine(5-HT),clinical efficacy,and incidence of adverse reactions were compared between the two groups.ResultsAfter 4 weeks of treatment,GSH-Px and SOD in both groups increased,while MDA decreased(P<0.05);after 4 weeks of treatment,the observation group had higher GSH-Px,higher SOD and lower MDA compared with the control group(P<0.05).After 4 weeks of treatment,SP and NPY in both groups decreased,and 5-HT increased(P<0.05);after 4 weeks of treatment,the observation group had lower SP,lower NPY and higher 5-HT compared with the control group(P<0.05).The clinical total effective rate of the observation group(94.29%,33/35)was higher than that of the control group(77.14%,27/35),P<0.05.No obvious adverse reaction was found in either group during treatment.ConclusionsThe combination therapy of pregabalin and carbamazepine can effectively regulate levels of oxidative stress indicators and serum pain mediators in patients with TN,and alleviate pain symptoms,which is safe and effective.

关 键 词：三叉神经痛 普瑞巴林 卡马西平 

分 类 号：R745.11[医药卫生—神经病学与精神病学]