Degree centrality values in the left calcarine as a potential imaging biomarker for anxious major depressive disorder  

作　　者：Yu-Jun Gao Li-Li Meng Zhao-Yuan Lu Xiang-You Li Ru-Qin Luo Hang Lin Zhi-Ming Pan Bao-Hua Xu Qian-Kun Huang Zhi-Gang Xiao Ting-Ting Li E Yin Nian Wei Chen Liu Hong Lin 

机构地区：[1]Department of Psychiatry,Wuhan Wuchang Hospital,Wuhan 430064,Hubei Province,China [2]Department of Psychiatry,Yichang Mental Health Center,Yichang 443000,Hubei Province,China [3]Institute of Mental Health,Three Gorges University,Yichang 443000,Hubei Province,China [4]Department of Psychiatry,Yichang City Clinical Research Center for Mental Disorders,Yichang 443000,Hubei Province,China [5]Department of Psychiatry,Wuhan Mental Health Center,Wuhan Hospital of Psychotherapy,Wuhan 430030,Hubei Province,China [6]Department of Nephrology,Wuhan Wuchang Hospital,Wuhan University of Science and Technology,Wuhan 430064,Hubei Province,China [7]Department of Nephrology,Xiaogan Central Hospital,Xiaogan 432000,Hubei Province,China

出　　处：《World Journal of Psychiatry》2025年第4期60-72,共13页世界精神病学杂志(英文)

基　　金：Supported by Hubei Provincial Department of Science and Technology Natural Fund,No.2024AFC056;the Open Fund of the Mental Health Research Institute at Three Gorges University,No.YCXL-23-11.

摘　　要：BACKGROUND Major depressive disorder(MDD)with comorbid anxiety is an intricate psychiatric condition,but limited research is available on the degree centrality(DC)between anxious MDD and nonanxious MDD patients.AIM To examine changes in DC values and their use as neuroimaging biomarkers in anxious and non-anxious MDD patients.METHODS We examined 23 anxious MDD patients,30 nonanxious MDD patients,and 28 healthy controls(HCs)using the DC for data analysis.RESULTS Compared with HCs,the anxious MDD group reported markedly reduced DC values in the right fusiform gyrus(FFG)and inferior occipital gyrus,whereas elevated DC values in the left middle frontal gyrus and left inferior parietal angular gyrus.The nonanxious MDD group exhibited surged DC values in the bilateral cerebellum IX,right precuneus,and opercular part of the inferior frontal gyrus.Unlike the nonanxious MDD group,the anxious MDD group exhibited declined DC values in the right FFG and bilateral calcarine(CAL).Besides,declined DC values in the right FFG and bilateral CAL negatively correlated with anxiety scores in the MDD group.CONCLUSION This study shows that abnormal DC patterns in MDD,especially in the left CAL,can distinguish MDD from its anxiety subtype,indicating a potential neuroimaging biomarker.

关 键 词：Major depressive disorder ANXIETY Degree centrality Resting-state functional magnetic resonance imaging 

分 类 号：R74[医药卫生—神经病学与精神病学]