Disorders of gut-brain interaction are a new challenge of our increasingly complex society,with worldwide repercussions  

作　　者：Earl B Ettienne Klaus Rose 

机构地区：[1]College of Pharmacy,Howard University College of Pharmacy,Washington,DC 20059,United States [2]Pediatric Drug Development and More,Medical Science,Riehen CH-4125,Switzerland

出　　处：《World Journal of Clinical Pediatrics》2025年第2期5-8,共4页世界临床儿科杂志(英文)

摘　　要：The term disorders of gut-brain interaction(DGBIs)encompasses gastrointestinal disorders that globally affect more than one third of all people.The Rome IV criteria replaced the former term“functional gastrointestinal disorders.”DGBIs can seriously challenge health and quality of life(QoL).A traditional but outdated approach differentiated“organic”vs“functional”disorders,seen by some as real vs psychiatric or undefined ones.This traditional distinction did not help patients whose health and QoL are seriously affected.DGBIs include motility disturbance;visceral hypersensitivity;altered mucosal and immune function;altered central nervous system processing,and more.Several DGBIs affect both children and adolescents.DGBIs are characterized by clusters of symptoms.Their pathophysiology relates to combinations of altered motility,visceral sensitivity,mucosal immune function,and more.Routine investigations find no structural abnormality that would easily explain the symptoms.Symptom-based criteria were developed to better understand patients where no mechanistic explanation was available for clinical practice and inclusion into clinical trials.To understand DGBIs and to find ways to treat them,these rigid mechanistic views fall short.

关 键 词：Disorders of gut-brain interaction American Psychiatric Association Rome foundation Rome IV Gut-brain-axis Functional diseases Psychiatric diseases Mechanistic approaches Symptom-based criteria Clinical trials Drugs Biologics 

分 类 号：R57[医药卫生—消化系统]