Uveitis associated with juvenile idiopathic arthritis and chronic idiopathic uveitis in children:A retrospective cohort study  

作　　者：Alexandr Alexandrovich Yakovlev Ekaterina Vladimirovna Gaidar Lyubov Sergeevna Sorokina Tatiana Nikolaevna Nikitina Olga Valerievna Kalashnikova Mikhail Mikhailovich Kostik 

机构地区：[1]Hospital Pediatry,Saint-Petersburg State Pediatric Medical University,Saint Petersburg 194100,Russia [2]Department of Ophthalmology,Saint-Petersburg State Pediatric Medical University,Saint Petersburg 194100,Russia

出　　处：《World Journal of Clinical Pediatrics》2025年第2期56-68,共13页世界临床儿科杂志(英文)

摘　　要：BACKGROUND Chronic idiopathic uveitis(CIU)and juvenile idiopathic arthritis-associated uveitis(U-JIA)are both vision-threatening conditions that share similar autoimmune mechanisms,but treatment approaches differ significantly.In managing U-JIA,various treatment options are employed,including biological and non-biological disease-modifying anti-rheumatic drugs.These drugs are effective in clinical trials.Given the lack of established diagnostic and treatment guidelines as well as the limited number of therapeutic options available,patients with CIU frequently do not receive optimal and timely immunosuppression.This study highlighted the necessity for additional research to develop novel diag-nostic techniques,targeted therapies,and enhanced treatment outcomes for young individuals with CIU.AIM To compare the characteristics and outcomes of U-JIA and CIU.METHODS A retrospective cohort study analyzed data from 110 pediatric patients(under 18 years old)with U-JIA and 40 pediatric patients with CIU.Data was collected between 2012 and 2023.The study focused on demographic,clinical,treatment,and outcome variables.RESULTS The median onset age of arthritis was 6.4 years(2.7 years;9.3 years).In 28.2%of cases uveitis preceded the onset of arthritis.In 17.3%of cases it occurred simultan-eously.In 53.6%of cases it followed arthritis.Both groups had similar onset ages,antinuclear antibodies/human leukocyte antigen positivity rates,and ESR levels,with a slight predominance of females(60.9%vs 42.5%,P=0.062),and higher C-reactive protein levels in the U-JIA group.Anterior uveitis was more prevalent in patients with U-JIA(P=0.023),although the frequency of symptomatic,unilateral,and complicated forms did not differ significantly.The use of methotrexate(83.8%vs 96.4%)and biologics(64.7%vs 82.1%)was comparable,as was the rate of remission on methotrexate treatment(70.9%vs 56.5%)and biological therapy(77.8%vs 95%),but a immunosuppressive treatment delay in CIU observed.Patients with CIU were less likely to receive methotrexate[hazar

关 键 词：UVEITIS Juvenile idiopathic arthritis IRIDOCYCLITIS Anterior uveitis Idiopathic uveitis BIOLOGICS Cohort study 

分 类 号：R75[医药卫生—皮肤病学与性病学]