Diagnostic and therapeutic considerations for primary penal synovial sarcoma with specific MDM2 gene amplification:A case report  

作　　者：Chao-Hua Deng Yuan Zhou Jing Chen Guo-Fu He Qun-Shan Fu Jiong-Ming Li Guang Wang Xiao-Dong Hu 

机构地区：[1]Department of Urology,The Fourth Affiliated Hospital of Dali University,Chuxiong 675000,Yunnan Province,China [2]Department of Nuclear Magnetic Resonance,The Fourth Affiliated Hospital of Dali University,Chuxiong 675000,Yunnan Province,China [3]Department of Computed Tomography,The Fourth Affiliated Hospital of Dali University,Chuxiong 675000,Yunnan Province,China [4]Department of Pathology,The Fourth Affiliated Hospital of Dali University,Chuxiong 675000,Yunnan Province,China [5]The Third Ward of Department of Urology,The Second Affiliated Hospital of Kunming Medical University,Kunming 675000,Yunnan Province,China

出　　处：《World Journal of Clinical Urology》2025年第1期1-6,共6页世界临床泌尿杂志(英文)

基　　金：Supported by The Joint Special Project of Universities in Yunnan Province in 2022,No.2022-ES-530101-207;The Hospital-level Scientific Research Project of The Fourth Affiliated Hospital of Dali University,No.2024YJ14.

摘　　要：BACKGROUND Primary renal synovial sarcoma(PRSS)is extremely rare in clinical practice,and most cases are associated with SYT-SSX gene fusion.The PRSS with specific MDM2 gene amplification has not been reported so far.Therefore,there is no practical experience regarding the clinical,pathological features and diagnosis and treatment plans for patients of this type.This article reports a case of PRSS with specific MDM2 gene amplification.CASE SUMMARY The patient was preoperatively diagnosed with a malignant tumor of the left kidney(with a high probability of clear cell carcinoma).During the operation,a radical left nephrectomy was performed.The postoperative pathological examination report confirmed synovial sarcoma,and the gene test suggested PRSS with specific MDM2 gene amplification.Forty-eight days after the operation,the patient presented with"abdominal distension and diarrhea"and was found to have a huge metastatic tumor in the original left renal area.The patient died clinically 17 hours after admission due to"multiple organ failure".CONCLUSION PRSS with MDM2 gene amplification has a poorer prognosis,a higher degree of malignancy,and a faster progression,and clinicians need to be highly vigilant.

关 键 词：Primary renal synovial sarcoma Renal tumor Clinical features Treatment Prognosis Case report 

分 类 号：R73[医药卫生—肿瘤]