Comprehensive review of Clostridium difficile infection:Epidemiology,diagnosis,prevention,and treatment  

作　　者：Xue Wang Wen-Yue Wang Xue-Lu Yu Jing-Wen Chen Ji-Shun Yang Ming-Ke Wang 

机构地区：[1]Naval Medical Center of People's Liberation Army,Naval Medical University,Shanghai 200052,China [2]Department of Emergency,Qinhuangdao Hospital of Integrated Traditional Chinese and Western Medicine,Hebei Port Group Co.,Ltd.,Qinhuangdao 066002,Hebei Provence,China [3]School of Pharmacy,Bengbu Medical University,Bengbu 233000,Anhui Province,China

出　　处：《World Journal of Gastrointestinal Pharmacology and Therapeutics》2025年第1期1-9,共9页世界胃肠药理与治疗学杂志(英文)

摘　　要：In recent years,nosocomial infections caused by Clostridium difficile(C.difficile)have risen,becoming a leading cause of hospital-acquired diarrhea.The global prevalence of C.difficile infection(CDI)varies across regions and populations.The diagnosis relies primarily on laboratory testing,including toxin,glutamate dehy-drogenase,and nucleic acid amplification tests.Treatment strategies for CDI in-clude antimicrobial therapy(e.g.,metronidazole,vancomycin,and fidamycin),fecal transplantation,and immunotherapy(e.g.,belotozumab),depending on the patient’s specificity and severity.This paper reviews recent research on CDI’s epidemiological characteristics,risk factors,diagnosis,treatment,and prevention,aiming to support hospitals and public health initiatives in implementing effective detection,prevention,and treatment strategies.

关 键 词：Clostridium difficile Pseudomembranous colitis Public health safety EPIDEMIOLOGY PREVENTION Diagnosis and treatment 

分 类 号：R57[医药卫生—消化系统]