Risk factors associated with the development of chronic pouchitis following ileal-pouch anal anastomosis surgery for ulcerative colitis  

作　　者：Emi Khoo Robert Gilmore Alison Griffin Gerald Holtmann Jakob Begun 

机构地区：[1]Department of Gastroenterology,Mater Hospital Brisbane,South Brisbane 4101,Queensland,Australia [2]IBD Clinical Trial Unit,Mater Research Institute,South Brisbane 4101,Queensland,Australia [3]Faculty of Medicine,University of Queensland,St Lucia 4067,Queensland,Australia [4]QIMR Berghofer Medical Research Institute,Herston 4006,Queensland,Australia [5]Department of Gastroenterology,Princess Alexandra Hospital,Woolloongabba 4102,Queensland,Australia

出　　处：《World Journal of Meta-Analysis》2025年第1期46-56,共11页世界荟萃分析杂志(英文)

摘　　要：BACKGROUND Chronic pouchitis remains a significant and prevalent complication following ileal pouch-anal anastomosis in patients with ulcerative colitis.AIM To identify potential risk factors for the development of chronic pouchitis.METHODS Predictors of chronic pouchitis were investigated through a systematic review and meta-analysis.A comprehensive search of the Medline,EMBASE,and PubMed databases was undertaken to identify relevant studies published up to October 2023.Meta-analytic procedures employed random-effects models for the combination of estimates,with the I^(2)statistic used to assess between-study heterogeneity.RESULTS Eleven studies with a total of 3722 patients,comprising 513 with chronic pouchitis and 3209 patients without,were included in the final analysis.Extraintestinal manifestation[odds ratio(OR)=2.11,95%confidence intervals(CI):1.53-2.91,P<0.001,I^(2)=0%],specifically primary sclerosing cholangitis(PSC)(OR=3.69,95%CI:1.40-9.21,P=0.01,I2=48%),and extensive colitis(OR=1.96,95%CI:1.23-3.11,P=0.00,I^(2)=31%)were associated with an increased risk of chronic pouchitis.Other factors,including gender,smoking status,family history of inflammatory bowel disease and ileal pouch anal anastomosis surgical indication were not significantly associated with chronic pouchitis.CONCLUSION Extraintestinal manifestations,PSC and extensive colitis are associated with the development of chronic pouchitis.These findings underscore the importance of comprehensive pre-operative assessment and tailored post operative management strategies.

关 键 词：Ulcerative colitis Ileal pouch-anal anastomosis POUCH Chronic pouchitis Risk factor 

分 类 号：R57[医药卫生—消化系统]