Control observation of different digestive tract reconstruction methods in total gastrectomy for gastric cancer  

作　　者：Ming Wei Hai-Bo Jiang Yuan-Yuan Wang Ya-Hong Shi Zhe Han Ying-Chao Gao 

机构地区：[1]Department of Gastroenterology,Second Department of Diagnosis and Treatment,The First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei Province,China [2]Department of Stomatology,Second Hospital of Shijiazhuang,Shijiazhuang 050000,Hebei Province,China [3]Department of Gastrointestinal Diagnosis and Treatment,First Hospital of Hebei Medical University,Shijiazhuang 050031,Hebei Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第4期132-139,共8页世界胃肠外科杂志(英文)

摘　　要：BACKGROUND For patients with advanced gastric cancer,surgical resection remains the main treatment option.Total gastrectomy combined with radical resection of gastric cancer lesions and sentinel lymph nodes can significantly prolong the survival of patients.Digestive tract reconstruction after total gastrectomy is essential to maintain gastrointestinal function and optimize postoperative recovery.Therefore,it is very important to choose a suitable reconstruction method to improve the quality of life of total gastrectomy patients.AIM To evaluate the effects of different digestive tract reconstruction methods in gastric cancer patients undergoing total gastrectomy.METHODS This retrospective study included 172 patients who underwent total gastrectomy for gastric cancer at The First Hospital of Hebei Medical University for analysis.The patients were categorized into two groups:Group A,consisting of 90 patients who underwent modified Roux-en-Y gastrojejunostomy,and group B,consisting of 82 patients who underwent uncut Roux-en-Y gastrojejunostomy.The general patient characteristics,perioperative indicators,postoperative gastrointestinal mucosal barrier function,nutritional status,immunological markers,and occurrence of complications were compared between the two groups.RESULTS Group A showed shorter digestive tract reconstruction time than group B(P<0.05).On the first postoperative day,group A showed lower serum levels of D-lactate,diamine oxidase,and endotoxin than group B(P<0.05).One month postoperatively,group A showed higher prognostic nutritional index,serum albumin,total protein,and body weight than group B(P<0.05).One month postoperatively,the levels of cluster of differentiation(CD)3+,CD4+,and CD8+cells were not significantly different between two groups(P>0.05).The complication rates were 10.00%in group A and 24.39%in group B;group A had a significantly lower complication rate than group B(P<0.05).CONCLUSION Using modified Roux-en-Y gastrojejunostomy during total gastrectomy shortens the time required for gast

关 键 词：Total gastrectomy Digestive tract reconstruction Gastric cancer Gastrointestinal barrier Immune function Safety 

分 类 号：R73[医药卫生—肿瘤]