Magnetic resonance imaging bias field correction improves tumor prognostic evaluation after transcatheter arterial chemoembolization for liver cancer  

作　　者：Ke Liu Jun-Biao Li Yong Wang Yan Li 

机构地区：[1]Department of Hepatology,The Infectious Disease Hospital of Xuzhou,Xuzhou 221018,Jiangsu Province,China [2]Department of Interventional Radiology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第4期207-220,共14页世界胃肠外科杂志(英文)

摘　　要：BACKGROUND Transcatheter arterial chemoembolization(TACE)is a key treatment approach for advanced invasive liver cancer(infiltrative hepatocellular carcinoma).However,its therapeutic response can be difficult to evaluate accurately using conventional two-dimensional imaging criteria due to the tumor’s diffuse and multifocal growth pattern.Volumetric imaging,especially enhanced tumor volume(ETV),offers a more comprehensive assessment.Nonetheless,bias field inhomogeneity in magnetic resonance imaging(MRI)poses challenges,potentially skewing volumetric measurements and undermining prognostic evaluation.AIM To investigate whether MRI bias field correction enhances the accuracy of volumetric assessment of infiltrative hepatocellular carcinoma treated with TACE,and to analyze how this improved measurement impacts prognostic prediction.METHODS We retrospectively collected data from 105 patients with invasive liver cancer who underwent TACE treatment at the Affiliated Hospital of Xuzhou Medical University from January 2020 to January 2024.The improved N4 bias field correction algorithm was applied to process MRI images,and the ETV before and after treatment was calculated.The ETV measurements before and after correction were compared,and their relationship with patient prognosis was analyzed.A Cox proportional hazards model was used to evaluate prognostic factors,with Martingale residual analysis determining the optimal cutoff value,followed by survival analysis.RESULTS Bias field correction significantly affected ETV measurements,with the corrected baseline ETV mean(505.235 cm³)being significantly lower than before correction(825.632 cm³,P<0.001).Cox analysis showed that the hazard ratio(HR)for corrected baseline ETV(HR=1.165,95%CI:1.069-1.268)was higher than before correction(HR=1.063,95%CI:1.031-1.095).Using 412 cm³as the cutoff,the group with baseline ETV<415 cm³had a longer median survival time compared to the≥415 cm³group(18.523 months vs 8.926 months,P<0.001).The group with an ETV reduction rate≥41%had

关 键 词：Invasive liver cancer Transcatheter arterial chemoembolization Magnetic resonance imaging Bias field correction Volume imaging 

分 类 号：R73[医药卫生—肿瘤]