Relationship between peripheral blood endotoxin, toll-like receptor 4 expression, and postoperative infection following surgery for acute appendicitis  

作　　者：Wei Su Tao Yang Xiao-Jun Hu Juan Song Jing-Jing He Dan Huang Bo Zhang Xiao-Ji Zhao Fang Tang 

机构地区：[1]Department of Clinical Laboratory,Mianyang Central Hospital,School of Medicine of University of Electronic Science and Technology of China,Mianyang 621000,Sichuan Province,China [2]Department of Clinical Laboratory,Santai Country People’s Hospital,Mianyang 621100,Sichuan Province,China [3]Department of Nuclear Medicine,The Second Affiliated Hospital of Chengdu Medical College,Nuclear Industry 416 Hospital,Chengdu 610083,Sichuan Province,China [4]Department of Clinical Laboratory,The Third Hospital of Mianyang,Sichuan Mental Health Center,Mianyang 621000,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第4期283-289,共7页世界胃肠外科杂志(英文)

摘　　要：BACKGROUND Acute appendicitis,a common condition with a higher prevalence among men,has shown an increasing incidence in recent years owing to lifestyle changes.It is characterized by right lower quadrant abdominal pain,rebound tenderness,and rapid onset.Its pathogenesis is complex and potentially linked to infection,environment,and genetics.Timely intervention is crucial to prevent complications.While surgery is the primary treatment,it carries risks,including postoperative infections that may necessitate re-operation.Gram-negative bacteria release endotoxin(ETX),which induces inflammation and is recognized by toll-like receptor 4(TLR4).This study evaluated ETX and TLR4 levels in patients with acute appendicitis to assess the risk of postoperative incision infections,aiding in prevention and treatment.AIM To explore ETX and TLR4 expression in the blood of patients with acute appendicitis and its association with in postoperative incision infection.METHODS A total of 153 patients with acute appendicitis treated at our hospital between April 2022 and March 2024(n=153)were included in the study.Patients were categorized into infected(n=36)and uninfected(n=117)groups according to the development of postoperative incision infections.General characteristics and blood levels of ETX and TLR4 were compared,and the factors influencing postoperative infection were identified using multivariate logistic regression.ETX and TLR4 predictive values were analyzed using receiver operating characteristic curves.RESULTS No statistically significant differences were observed between the two groups in terms of sex,age,or other general characteristics(P>0.05).Compared to the uninfected group,the infected group had a higher proportion of patients with suppurative or gangrenous appendicitis,longer surgical times,longer incision lengths,and elevated ETX and TLR4 levels(P<0.05).Multivariate logistic regression analysis identified pathological type,surgical method,surgical time,and incision length as factors influencing postoperative incis

关 键 词：Acute appendicitis ENDOTOXIN Toll-like receptor 4 Risk factors Wound infection 

分 类 号：R73[医药卫生—肿瘤]