Prediction of perioperative complications in colorectal cancer via artificial intelligence analysis of heart rate variability  

作　　者：Miao-Miao Ge Li-Wen Wang Jun Wang Jiang Liu Peng Chen Xin-Xin Liu Gang Wang Guan-Wen Gong Zhi-Wei Jiang 

机构地区：[1]Department of General Surgery,Jiangsu Province Hospital of Chinese Medicine,The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210000,Jiangsu Province,China [2]School of Chinese Medicine,Hong Kong Baptist University,Hong Kong 000000,Hong Kong,China [3]Department of General Surgery,Xuzhou Traditional Chinese Medicine Hospital,The Affiliated to Nanjing University of Chinese Medicine,Xuzhou 221000,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第4期290-299,共10页世界胃肠外科杂志(英文)

基　　金：Supported by The Natural Science Foundation of Nanjing University of Chinese Medicine,No.XZR2021019;The Outstanding Young Doctor Program of Jiangsu Province of Chinese Medicine,No.2023QB0140;Project of National Clinical Research Base of Traditional Chinese Medicine in Jiangsu Province,No.JD2022SZ18;The Natural Science Foundation of Nanjing University of Chinese Medicine,No.KYCX21_1710.

摘　　要：BACKGROUND Heart rate variability(HRV)represents efferent vagus nerve activity,which is suggested to be related to fundamental mechanisms of tumorigenesis and to be a predictor of prognosis in various cancers.Therefore,this study hypothesized that HRV monitoring could predict perioperative complication(PC)in colorectal cancer(CRC)patients.AIM To investigate the prognostic value of HRV in hospitalized CRC patients.METHODS The observational studies included 87 patients who underwent CRC surgical procedures under enhanced recovery after surgery programs in a first-class hospital.The HRV parameters were compared between the PC group and the non PC(NPC)group from preoperative day 1 to postoperative day(Pod)3.In addition,inflammatory biomarkers and nutritional indicators were also analyzed.RESULTS The complication rate was 14.9%.HRV was markedly abnormal after surgery,especially in the PC group.The frequency-domain parameters(including pNN50)and time-domain parameters[including high-frequency(HF)]of HRV were significantly different between the two groups postoperatively.The pNN50 was significantly greater at Pod1 in the PC group than that in the NPC group and returned to baseline at Pod2,suggesting that patients with complications exhibited autonomic nerve dysfunction in the early postoperative period.In the PC group,HFs were also enhanced from Pod1 and were significantly higher than in the NPC group;inflammatory biomarkers were significantly elevated at Pod2 and Pod3;the levels of nutritional indicators were significantly lower at Pod1 and Pod2;and the white blood cell count was slightly elevated at Pod3.CONCLUSION HRV is independently associated with postoperative complications in patients with CRC.Abnormal HRV could predicted an increased risk of postoperative complications in CRC patients.Continuous HRV could be used to monitor complications in patients with CRC during the perioperative period.

关 键 词：Colorectal cancer Heart rate variability COMPLICATIONS Perioperative period PREDICTION 

分 类 号：R73[医药卫生—肿瘤]