Laparoscopic management of intraductal oncocytic papillary neoplasm of the pancreas: Two case reports and review of literature  

作　　者：Guo-Zhen Wu Li-Na Lu Hai-Ping Lin Xin-Yu Wang Shi-An Yu Min Yu 

机构地区：[1]Department of Hepatobiliary and Pancreatic Surgery,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Jinhua 321000,Zhejiang Province,China [2]Department of Gastroenterology,Wenrong Hospital of Jinhua City,Jinhua 321000,Zhejiang Province,China [3]Department of Radiology,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Jinhua 321000,Zhejiang Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2025年第4期418-427,共10页世界胃肠外科杂志(英文)

基　　金：Supported by the Zhejiang Medical Science and Technology Project,No.2022KY1325 and No.2023KY381.

摘　　要：BACKGROUND Intraductal oncocytic papillary neoplasm(IOPN)of the pancreas is an extremely rare pancreatic tumor,with only sporadic cases reported in the literature.IOPN is difficult to diagnose and highly prone to misdiagnosis.IOPN carries a certain risk of progressing to invasive cancer.Surgical resection is the primary treatment for IOPN.According to the existing literature reports,the vast majority of patients with IOPN of the pancreas undergo open surgery,while only one case of laparoscopic surgery have been reported.CASE SUMMARY This report presents two cases of IOPN in elderly female patients,aged 60 and 61.Both patients were asymptomatic,and their pancreatic masses were discovered incidentally.Preoperative diagnosis of IOPN is challenging and prone to misdiagnosis.In the first case,the patient underwent a laparoscopic distal pancreatectomy and splenectomy.The surgical procedure spanned 342 minutes,with an estimated intraoperative blood loss of around 100 mL.The patient experienced an uneventful postoperative recovery and was discharged on the 8th postoperative day.For the second case,a laparoscopic pancreaticoduodenectomy was performed.The operation lasted for 431 minutes with an intraoperative blood loss of approximately 50 mL.The patient also demonstrated a favorable postoperative course and was discharged on the 24^(th)postoperative day.Postoperative pathology and immunohistochemistry confirmed the diagnosis of IOPN.No recurrence was observed in either patient after follow-up periods of 8 and 10 months,respectively.CONCLUSION These cases demonstrate that laparoscopic surgery can be considered as one of the treatment options for IOPN of the pancreas.

关 键 词：Intraductal oncocytic papillary neoplasm PANCREAS Laparoscopic surgery MISDIAGNOSIS Case report 

分 类 号：R73[医药卫生—肿瘤]