Role of interleukins in the pathogenesis of coronary heart disease:A literature review  

作　　者：Saira Rafaqat Azeem Azam Ramsha Hafeez Hamza Faseeh Maria Tariq Muhammad Asif Amber Arshad Iqra Noshair 

机构地区：[1]Department of Zoology(Molecular Physiology),Lahore College for Women University,Lahore 54000,Pakistan [2]Institute of Zoology,University of the Punjab,Lahore 54000,Pakistan [3]Department of Zoology,Govt.Islamia Graduate College Civil Lines,Lahore 54000,Pakistan [4]Department of Zoology,University of Education,Lahore 54000,Pakistan

出　　处：《World Journal of Cardiology》2025年第3期41-57,共17页世界心脏病学杂志(英文)

摘　　要：Interleukins(ILs),a subset of cytokines,play a critical role in the pathogenesis of coronary heart disease(CHD)by mediating inflammation.This review article summarizes the role of ILs such as IL-1,IL-2,IL-3,IL-4,IL-5,IL-6,IL-7,IL-8,IL-9,and IL-10 in the pathogenesis of CHD.Individuals with mild coronary artery disease(CAD)and angina who have ischemic heart disease have higher serum concentrations of IL-1b.Larger studies are needed to verify the safety and assess the effectiveness of low-dose IL-2 as an anti-inflammatory treatment.IL-3 is found more often in patients receiving coronary angioplasty compared to patients with asymptomatic CAD or without CAD.Serum levels of IL-4 are reliable indicators of CAD.An independent correlation between IL-5 and the incidence of CAD was demonstrated.IL-6 helps serve as a reliable biomarker for the degree of CAD,as determined by the Gensini score,and is a key factor in the development of atherosclerosis.Also,variants of IL-7/7R have been linked to the Han Chinese population's genetic susceptibility to CHD.IL-8 plays a role in the progression of CAD occurrences.By interacting with conventional risk factors for CAD,IL-9 may contribute to the development of CAD and offer an innovative approach to its prevention and management.There was a 34%increased risk of a CHD incident for every standard deviation rise in baseline IL-10 levels.

关 键 词：Coronary heart disease INTERLEUKINS Inflammation PATHOGENESIS 

分 类 号：R54[医药卫生—心血管疾病]