Gut microbiota in the development and progression of chronic liver diseases:Gut microbiota-liver axis  

作　　者：Aysun Yakut 

机构地区：[1]Department of Gastroenterology,İstanbul Medipol University Sefakoy Health Practice Research Center,İstanbul 38000,Türkiye

出　　处：《World Journal of Hepatology》2025年第3期25-41,共17页世界肝病学杂志(英文)

摘　　要：The gut microbiota(GM)is a highly dynamic ecology whose density and com-position can be influenced by a wide range of internal and external factors.Thus,“How do GM,which can have commensal,pathological,and mutualistic rela-tionships with us,affect human health?”has become the most popular research issue in recent years.Numerous studies have demonstrated that the trillions of microorganisms that inhabit the human body can alter host physiology in a variety of systems,such as metabolism,immunology,cardiovascular health,and neurons.The GM may have a role in the development of a number of clinical disorders by producing bioactive peptides,including neurotransmitters,short-chain fatty acids,branched-chain amino acids,intestinal hormones,and secondary bile acid conversion.These bioactive peptides enter the portal circulatory system through the gut-liver axis and play a role in the development of chronic liver diseases,cirrhosis,and hepatic encephalopathy.This procedure is still unclear and quite complex.In this study,we aim to discuss the contribution of GM to the development of liver diseases,its effects on the progression of existing chronic liver disease,and to address the basic mechanisms of the intestinal microbiota-liver axis in the light of recent publications that may inspire the future.

关 键 词：Gut microbiota Gut microbiota-liver axis Liver diseases Treatment strategies and modeling Chronic liver diseases 

分 类 号：R57[医药卫生—消化系统]