Changes in Intestinal flora is associated with chronic diseases  

作　　者：Guo-Heng Jiang Hong-Yu Li Lin-Jun Xie Jing-Yuan Fan Shi-Yi Li Wen-Qian Yu Yi-Ting Xu Meng-Lin He Yi Jiang Xuan Bai Jin Zhou Xin Wang 

机构地区：[1]Department of Epidemiology and Biostatistics,West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [2]China Tobacco Sichuan Industry Co.Ltd.,Technology Center,Chengdu 610101,Sichuan Province,China [3]Department of Anorectal Surgery,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China

出　　处：《World Journal of Gastroenterology》2025年第11期183-197,共15页世界胃肠病学杂志(英文)

基　　金：Supported by National Natural Science Foundation of China,No.81903398;the Research Start-Up Fund for the Introduction of Talents of Sichuan University,No.YJ2021112;Medical Youth Innovation Research Project of Sichuan Province,No.Q21016;Natural Science Foundation of Sichuan,No.2023NSFSC1927;“From 0 to 1”Innovation Project,Sichuan University,No.2023SCUH0026;Sichuan Provincial Science and Technology Department 2023 Central Guide Local Project,No.2023ZYD0097;Cigar Fermentation Technology Key Laboratory of Tobacco Industry,No.20202309BC530.

摘　　要：BACKGROUND The intestinal flora(IF)has been linked to risks of non-communicable diseases,especially various cancers,stroke,and Alzheimer’s disease.However,many uncertainties of these associations during different stages of growth,deve-lopment,and aging still exist.Therefore,further in-depth explorations are warranted.AIM To explore the associations of the human IF with disease risks during different stages of growth,development,and aging to achieve more accurate and con-vincing conclusions.METHODS Cohort,cross-sectional,case-control,and Mendelian randomization studies published in the PubMed and Web of Science databases until December 31,2023 were systematically reviewed to clarify the associations of the IF at the genus level with the risks of various non-communicable diseases,which were grouped in accordance with the 10^(th) revision of the International Classification of Diseases.RESULTS In total,57 studies were included to quantitatively examine the influence of the IF on the risks of 30 non-communicable diseases during different stages of growth,development,and aging.Population studies and Mendelian randomization studies confirmed positive associations of the abundances of Bifidobacterium and Ruminococcus with multiple sclerosis.CONCLUSION These findings contribute to a deeper understanding of the roles of the IF and provide novel evidence for effective strategies for the prevention and treatment of non-communicable diseases.In the future,it will be necessary to explore a greater variety of research techniques to uncover the specific mechanisms by which gut microbiota trigger diseases and conduct in-depth studies on the temporal relationship between microbiota alterations and diseases,so as to clarify the causal relationship more accurately.

关 键 词：Intestinal flora Non-communicable diseases Occurrence risk Systematic review META-ANALYSIS 

分 类 号：R73[医药卫生—肿瘤]