Involvement of the NLRP3/IL-1βpathway in activation and effector functions ofγδT17 cells in patients with ulcerative colitis  

作　　者：Jing Ma Feng-Yun Wang Xu-Dong Tang 

机构地区：[1]Institute of Digestive Diseases,Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China

出　　处：《World Journal of Gastroenterology》2025年第12期82-90,共9页世界胃肠病学杂志(英文)

基　　金：Supported by China Academy of Chinese Medical Sciences Outstanding Young Talents(Innovative)Cultivation Project,No.ZZ17-YQ-007;Special Project of the National Natural Science Foundation of China,No.82341233.

摘　　要：BACKGROUND The interleukin-17(IL-17)mediated aberrant immune-inflammatory response plays a paramount role in ulcerative colitis(UC).γδT17 cells are one of the critical sources of IL-17,but the role they play in UC remains under debate.AIM To clarify the role ofγδT17 cells in patients with mild-to-moderate UC.METHODS A single-centre observational pragmatic study was conducted on patients with UC who attended the outpatient and inpatient departments of Xiyuan Hospital of the China Academy of Traditional Chinese Medicine from September 2020 to December 2022.The research population consisted of two groups of adult patients.The first group consisted of healthy volunteers with no significant abnormalities on colonoscopy,and the other group consisted of patients with mild-to-moderate ulcerative colitis.Serum samples from healthy volunteers and patients with UC were collected for the detection of relevant inflammatory factors.Moreover,five colon mucosa samples were randomly selected from each group for testing and analyses.RESULTS An increased number ofγδT17 cells and hyperactivation of the NLR family pyrin domain containing 3/IL-1βsignaling pathway were observed in colonic mucosal tissues from patients with UC.CONCLUSION Hyperactivation of the NLR family pyrin domain containing 3/IL-1βsignaling pathway promotes the activation ofγδT17 cells in colonic mucosal tissues of patients with UC.

关 键 词：Ulcerative colitis Abnormal immune response γδT17 cells NLR family pyrin domain containing 3/interleukin-1βpathway Observational study 

分 类 号：R73[医药卫生—肿瘤]