左乙拉西坦+丙戊酸钠治疗小儿颅脑外伤后癫痫的总有效率及对认知功能的影响  

The Total Effective Rate of Levetiracetam and Sodium Valproate in the Treatment of Epilepsy After Craniocerebral Trauma in Children and its Effect on Cognitive Function

作　　者：李政委 朱炳鑫 岳成龙 朱永琦 韩正中 LI Zhengwei;ZHU Bingxin;YUE Chenglong;ZHU Yongqi;HAN Zhengzhong(Department of Neurosurgery,Xuzhou Children's Hospital,Xuzhou 221000,Jiangsu,China)

机构地区：[1]徐州市儿童医院神经外科,江苏徐州221000

出　　处：《医学信息》2025年第6期131-134,共4页Journal of Medical Information

摘　　要：目的评价左乙拉西坦+丙戊酸钠治疗小儿颅脑外伤后癫痫的总有效率及对认知功能的影响。方法选取2020年1月-2024年10月徐州市儿童医院收治的60例颅脑外伤后癫痫患儿作为研究对象,按照随机数字表法将其分为对照组和研究组,每组30例。对照组应用左乙拉西坦治疗,研究组应用丙戊酸钠联合左乙拉西坦治疗。比较两组临床疗效、认知功能[操作智商(PIQ)、语言智商(VIQ)、总智商(FIQ)]、神经损伤标志物水平(S-100β蛋白、神经元特异性烯醇化酶)、不良反应(食欲不振、头晕嗜睡、皮疹瘙痒)发生率。结果研究组治疗总有效率高于对照组(P<0.05);研究组治疗后认知功能评分均高于对照组(P<0.05);研究组神经损伤标志物水平均低于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论左乙拉西坦+丙戊酸钠治疗小儿颅脑外伤后癫痫的临床疗效确切,能够提高患儿治疗总有效率,改善患儿认知功能及神经损伤状况,且安全性较高。Objective To evaluate the total effective rate of levetiracetam+sodium valproate in the treatment of epilepsy after craniocerebral trauma in children and its effect on cognitive function.Methods A total of 60 children with epilepsy after craniocerebral trauma admitted to Xuzhou Children's Hospital from January 2020 to October 2024 were selected as the research objects.According to the random number table method,they were divided into control group and study group,with 30 children in each group.The control group was treated with levetiracetam,and the study group was treated with sodium valproate combined with levetiracetam.The clinical efficacy,cognitive function[performance intelligence quotient(PIQ),verbal intelligence quotient(VIQ),full intelligence quotient(FIQ)],levels of nerve injury markers(S-100βprotein,neuron-specific enolase),and incidence of adverse reactions(loss of appetite,dizziness,drowsiness,rash and pruritus)were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).After treatment,the scores of cognitive function in the study group were higher than those in the control group(P<0.05).The levels of nerve injury markers in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Levetiracetam+sodium valproate is effective in the treatment of epilepsy after craniocerebral trauma in children,which can improve the total effective rate of treatment,improve the cognitive function and nerve injury of children,and has high safety.

关 键 词：左乙拉西坦 丙戊酸钠 小儿颅脑外伤后癫痫 认知功能 

分 类 号：R741[医药卫生—神经病学与精神病学]