恒通汤对结直肠癌根治术后胃肠功能恢复的临床观察  

Clinical Study of Hengtong Decoction in Promoting Gastrointestinal Function Recovery after Radical Resection of Colorectal Cancer

作　　者：武明胜 李一金 刘景 唐彦博 WU Ming-sheng;LI Yi-jin;LIU Jing;TANG Yan-bo(Department of Proctology,Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Changsha Hunan 410006)

机构地区：[1]湖南省中西医结合医院肛肠科,湖南长沙410006

出　　处：《世界中西医结合杂志》2025年第3期546-551,共6页World Journal of Integrated Traditional and Western Medicine

基　　金：2023年度湖南省中医药科研课题(B2023105)。

摘　　要：目的观察恒通汤对结直肠癌根治术患者术后胃肠功能恢复的影响。方法选取2023年1月—2024年6月期间湖南省中医药研究院结直肠肛门外科收治的结直肠癌患者120例,按照随机数字表法分为对照组和研究组,每组各60例。对照组患者接受常规围术期干预,研究组患者在对照组基础上加用恒通汤干预。观察比较两组患者术后排气、排便时间,比较两组患者术后7 d内腹痛、腹胀发生例数及程度差异,比较两组患者术后实验室指标[白细胞计数(White blood cell count,WBC)、血红蛋白(Hemoglobin,Hb)、血清白蛋白(Albumin,ALB)、谷丙转氨酶(Glutamic-pyruvic transaminase,ALT)、天门冬氨酸转氨酶(Aspartate aminotransferase,AST)、肌酐(Creatinine,Cr)]、住院时间和费用差异、临床疗效和并发症发生率。结果术后研究组首次排气时间和排便时间低于对照组,差异有统计学意义(P<0.05)。术后3 d及术后7 d时,研究组患者0~2级疼痛占比明显高于对照组,腹胀得分0~1级占比明显高于对照组,差异有统计学意义(P<0.05)。术后1 d、术后3 d以及术后7 d两组患者WBC、Hb、ALB、ALT、AST、Cr水平组间比较,差异无统计学意义(P>0.05)。治疗后研究组临床总有效率100%(60/60)高于对照组96.67%(58/60),差异有统计学意义(P<0.05)。术后研究组患者住院天数、住院费用均明显低于对照组,差异有统计学意义(P<0.05)。治疗期间,研究组并发症总发生率11.67%(7/60)明显低于对照组31.67%(19/60),差异有统计学意义(P<0.05)。结论恒通汤有助于加速结直肠癌根治术患者术后排气和排便,减轻患者腹痛和腹胀症状,减少患者术后并发症发生率,降低患者住院时间及费用,同时不会对患者术后肝肾功能造成不良影响。Objective To analyze the effect of Hengtong decoction in promoting gastrointestinal function recovery after radical resection of colorectal cancer.Methods From January 2023 to June 2024,120 patients with colorectal cancer admitted to the department of colorectal anorectal surgery,Hunan Academy of Traditional Chinese Medicine were selected as the research objects.All patients received radical resection of colorectal cancer in the hospital,and they were divided into the study group(n=60)and the control group(n=60)using the random number table.Patients in the control group were administered routine perioperative intervention while patients in the study group were additionally treated with Hengtong Decoction.The following aspects were observed and compared between both groups:the postoperative exhaust and defecation time,the number and degree of abdominal pain and distension within 7 days after operation,the postoperative laboratory indexes[White blood cell count(WBC),Hemoglobin(Hb),Serum Albumin(ALB),Glutamic-pyruvic Transaminase(ALT),Aspartate Aminotransferase(AST),Creatinine(Cr)],as well as differences in length and expenses of hospital stay,clinical efficacy,and incidences of complications.Results The time of first exhaust and defecation in the study group was earlier than that in the control group(P<0.05).In the study group,the proportion of 0-2 degree pain,and the proportion of 0-1 degree in score of abdominal distension was obviously higher on the 3rd and 7th day after operation compared to the control group(P<0.05).There was no significant difference in WBC,Hb,ALB,ALT,AST,or Cr between the two groups on the 1st,3rd,and 7th day after operation(P>0.05).After treatment,the overall clinical efficacy of the study group(100%,60/60)was higher than that of the control group(96.67%,58/60)(P<0.05).The postoperative length and expenses of hospital stay as well as operation time were significantly lower in the study group(P<0.05).During treatment,the total incidence of complications in the study group was 11.67%(7/60),lo

关 键 词：恒通汤 结直肠癌 根治术 胃肠功能 并发症 

分 类 号：R735.37[医药卫生—肿瘤]