不同疝补片对伤口愈合胶原蛋白沉积的影响  

Effect of different hernia patches on collagen deposition in wound healing

作　　者：黄雨琳 嵇振岭[1] Huang Yulin;Ji Zhenling(Department of General Surgery,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院普外科,南京210009

出　　处：《中华疝和腹壁外科杂志(电子版)》2025年第1期25-30,共6页Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition)

摘　　要：腹壁疝作为腹部外科常见的疾病之一,常常因为腹腔内脏器脱出而引起疼痛,甚至嵌顿导致脏器坏死等严重后果,故而多需要行手术治疗。其根本病因是腹壁薄弱,胶原蛋白失衡或者产生异常胶原纤维都将导致腹壁结缔组织的削弱、变薄,进而导致疝的发生及复发。大量研究已表明筋膜组织中Ⅰ型/Ⅲ型胶原蛋白的比例失调是导致腹股沟疝的主要因素。已有研究证明伤口愈合胶原蛋白沉积受补片类型的显著影响,然而,到目前为止,还没有研究调查不同移植材料对人体筋膜中胶原蛋白沉积和组织重塑的作用。本文归纳3 类(不可吸收补片,生物补片,人工合成的可吸收补片)疝补片对胶原蛋白的沉积所带来的影响。As one of the common diseases in abdominal surgery, abdominal wall hernia often causes pain caused by the prolapse of the abdominal cavity organs, and even causes serious consequences such as organ necrosis, so more surgical treatment is needed.The fundamental reason for this is that a weak abdominal wall, collagen imbalance, or abnormal collagen fibers can lead to weakening and thinning of the connective tissue of the abdominal wall, which in turn can lead to the development and recurrence of hernias.Numerous studies have shown that the proportional dysregulation of type I / typeⅢ of collagen in the fascial tissue is the main factor involved in the inguinal hernia.It has been demonstrated that wound-healing collagen deposition is significantly affected by patch type , however, to date, no studies have investigated the role of different graft materials on collagen deposition and tissue remodeling in the human fascia.This article summarizes the effects of 3 types of hernia patches (non-absorbable patches,biological patches, and synthetic absorbable patches) on collagen deposition.

关 键 词：腹壁疝 腹壁薄弱 胶原蛋白 疝补片 

分 类 号：R73[医药卫生—肿瘤]