18F-AlF-NOTA-OC PET/CT与MRI对神经内分泌肿瘤肝转移检出效能的比较  

Comparing the efficacies of 18F-AlF-NOTA-octreotide PET/CT and MRI in detecting liver metastases of neuroendocrine neoplasm

作　　者：蔺旭阳 王冉[1] 孙珂[1] 刘小婷[1] 张晓晗 韩星敏[1] Lin Xuyang;Wang Ran;Sun Ke;Liu Xiaoting;Zhang Xiaohan;Han Xingmin(Department of Nuclear Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院核医学科,郑州450052

出　　处：《中华核医学与分子影像杂志》2025年第3期149-153,共5页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：目的比较18F-AlF-1,4,7-三氮杂环壬烷-1,4,7-三乙酸(NOTA)-奥曲肽(OC)PET/CT显像与MRI对神经内分泌肿瘤肝转移(NENLM)病灶的检出效能。方法回顾性收集2021年7月至2023年12月于郑州大学第一附属医院经病理或临床随访证实为肝转移的44例神经内分泌肿瘤患者[男26例、女18例,年龄(53.8±13.4)岁]的资料,分析其18F-AlF-NOTA-OC PET/CT及MRI(包括MR动态增强扫描及弥散加权成像)检查结果。根据肝转移病灶大小分为长径≤1 cm、1 cm<长径≤2 cm及长径>2 cm 3组。根据2019 WHO病理分级将患者分为G1、G2、G3、神经内分泌癌4组。应用McNemarχ^(2)检验比较2种检查方式对肝转移患者及病灶检出情况的差异。结果18F-AlF-NOTA-OC PET/CT及MRI对肝转移患者的检出率均为95.45%(42/44)。44例患者中,18F-AlF-NOTA-OC PET/CT检出病灶227个,MRI检出病灶303个。基于病灶(n=307)分析,18F-AlF-NOTA-OC PET/CT对NENLM病灶的检出率低于MRI[73.94%(227/307)与98.70%(303/307);χ^(2)=66.96,P<0.001]。对于长径≤1 cm、1 cm<长径≤2 cm、长径>2 cm的肝转移灶,MRI检出率均高于18F-AlF-NOTA-OC PET/CT[98.72%(77/78)、93.55%(116/124)、97.35%(110/113)与47.44%(37/78)、73.39%(91/124)、87.61%(99/113);χ^(2)值:5.88~36.21,均P<0.05]。结论与18F-AlF-NOTA-OC PET/CT相比,MRI对不同长径NENLM病灶有更高的检出率,尤其对于长径≤1 cm的病灶。ObjectiveTo compare the efficacy of 18F-AlF-1,4,7-triazacyclononane-1,4,7-triacetic acid(NOTA)-octreotide(OC)PET/CT and MRI in detecting liver metastases(LM)of neuroendocrine neoplasm(NENLM).Methods 18F-AlF-NOTA-OC PET/CT and MRI findings(dynamic contrast enhanced MRI and diffusion weighted imaging)of 44 patients(26 males,18 females,age(53.8±13.4)years)with neuroendocrine neoplasm(NEN)confirmed by pathological or clinical follow-up in the First Affiliated Hospital of Zhengzhou University from July 2021 to December 2023 were retrospectively analyzed.According to the size of LM,patients were divided into 3 groups with long diameter≤1 cm,1 cm<long diameter≤2 cm and long diameter>2 cm.According to the 2019 WHO pathological grade,patients were divided into G1,G2,G3 and neuroendocrine carcinoma groups.McNemar χ^(2) test was used to compare the difference in detecting LM and lesions between the two methods.ResultsThe detection rate of 18F-AlF-NOTA-OC PET/CT and MRI in patients with NENLM was 95.45%(42/44).Among 44 patients,227 lesions were detected by PET/CT and 303 were detected by MRI.Based on lesion analysis(n=307),the detection rate of 18F-AlF-NOTA-OC PET/CT for NENLM was lower than that of MRI(73.94%(227/307)vs 98.70%(303/307);χ^(2)=66.96,P<0.001).For NENLM with long diameter≤1 cm,1 cm<long diameter≤2 cm,long diameter>2 cm,the detection rates of MRI were higher than those of 18F-AlF-NOTA-OC PET/CT(98.72%(77/78),93.55%(116/124),97.35%(110/113)vs 47.44%(37/78),73.39%(91/124),87.61%(99/113);χ^(2) values:5.88-36.21,all P<0.05).ConclusionsCompared with 18F-AlF-NOTA-OC PET/CT,MRI has a higher detection rate for NENLM with different long diameters of NEN,especially for lesions with long diameter≤1 cm.

关 键 词：神经内分泌瘤 肿瘤转移 肝 奥曲肽 正电子发射断层显像术 体层摄影术 X线计算机 磁共振成像 

分 类 号：R73[医药卫生—肿瘤]