DHH基因单核苷酸多态性与抑郁症的相关分析  

Association analysis of DHH gene single nucleotide polymorphism and depression

作　　者：陈婧婕 王艺羲 梁鹏 李悦 李健 梁芸丹 CHEN Jing-jie;WANG Yi-xi;LIANG Peng;LI Yue;LI Jian;LIANG Yun-dan(Basic Medical College,Chengdu Medical College,Chengdu 610500,China;School of Pharmaceutical Sciences,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院基础医学院,成都610500 [2]成都医学院药学院,成都610500

出　　处：《解剖学报》2025年第2期158-162,共5页Acta Anatomica Sinica

基　　金：四川省老年医学临床医学研究中心基金(24LHLNYX1-04);发育与再生四川省重点实验室基金(24LHFYSZ1-25);四川省应用心理学研究中心科研项目基金(CSXL-24202);成都医学院研究生科研创新基金(YCX2024-01-09)。

摘　　要：目的探讨DHH基因的rs7296288单核苷酸多态性(SNP)与抑郁症发病的相关性。方法收集2018年3月~2019年12月期间在四川省人民医院、济宁市精神病院、云南省精神卫生中心3家医院480例抑郁症患者作为病例组,329例非抑郁症作为对照组,采集外周血样本,提取血液中DNA,采用多重扩增和高通量测序技术对DHH基因rs7296288进行基因分型,并用统计学方法对抑郁症进行相关性分析。结果DHH基因的rs7296288多态位点AA型在对照组为32.9%,病例组为36.7%;AC基因型在对照组为52.8%,病例组为47.7%;CC基因型在对照组为14.3%,病例组为15.6%。共显性、显性、隐性统计学模型均无统计学意义。通过对抑郁发作程度、企图自杀和是否为首发患者的亚组分析,并未发现DHH基因的rs7296288 SNP位点与抑郁症临床特征之间有关联,即DHH基因rs7296288 SNP与抑郁症并无显著相关性。结论DHH基因rs7296288多态性与抑郁症的发病无相关性。Objective To explore the correlation between the rs7296288 single nucleotide polymorphism(SNP)of the DHH gene and the onset of depression.Methods From March 2018 to December 2019,480 patients with depression in Sichuan Provincial People’s Hospital,Jining Mental Hospital,Yunnan Mental Health Center were collected as the case group,and 329 patients without depression were collected as the control group.Peripheral blood samples were collected and DNA was extracted.After multiple amplification and high⁃throughput sequencing,statistical software was used to analyze the relevant data.Results The rs7296288 polymorphism of the DHH gene,the AA genotype was 32.9%in the control group and 36.7%in the case group,with no statistical difference;the AC genotype was 52.8%in the control group and 47.7%in the case group,with no statistical difference;the CC genotype was 14.3%in the control group and 15.6%in the case group,with no statistical difference.The co⁃dominant,dominant,and recessive statistical models were not statistically significant.Subgroup analysis of the degree of depressive episodes,suicide attempts,and first⁃episode patients did not find an association between the rs7296288 SNP locus of the DHH gene and the clinical features of depression,that is,the SNP rs7296288 of the DHH gene had no significant correlation with depression.Conclusion The rs7296288 polymorphism of DHH gene is not correlated with the pathogenesis of depression.

关 键 词：抑郁症 DHH基因 多重扩增 rs7296288 单核苷酸多态性位点 高通量测序 人 

分 类 号：R749[医药卫生—神经病学与精神病学]