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作 者:Mei-Jing Ren Zi-Li Zhang Can Tian Gui-Qiu Liu Chuan-Shan Zhang Hai-Bo Yu Qi Xin
机构地区:[1]Department of Pathology,Tianjin Third Center Hospital,Tianjin 300170,China [2]Department of Gastrointestinal Surgery,Tianjin Third Center Hospital,Tianjin 300170,China [3]Department of Laboratory,The Second Hospital of Tianjin Medical University,Tianjin 300211,China
出 处:《World Journal of Gastrointestinal Oncology》2025年第4期1-7,共7页世界胃肠肿瘤学杂志(英文)
基 金:Tianjin Third Central Hospital,No.2019YNR3.
摘 要:Multiple endocrine neoplasia type 1(MEN1)is an autosomal-inherited syndrome involving multiple endocrine tumors.It is characterized by multiple mutations in the tumor suppressor gene MEN1,which is located on chromosome 11q13.As main etiology of MEN1 is genetic mutations,clinical symptoms may vary.In this editorial,we comment on the article by Yuan et al.This article describes a case of(MEN1)characterized by low incidence and diagnostic complexity.MEN1 co-mmonly presents as parathyroid,pancreatic,and pituitary tumors.Diagnosis requires a combination of serologic tests,magnetic resonance imaging,computed tomography,endoscopic ultrasonography,immunologic and pathology.The diagnosis is unique depending on the site of disease.Surgical resection is the treatment of choice for MEN1.The prognosis depends on the site of origin,but early detection and intervention is the most effective.
关 键 词:Multiple endocrine neoplasia type 1 DIAGNOSIS Treatment Primary hyperparathyroidism Pancreatic neuroendocrine neoplasms
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