Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk  

作　　者：Xin Liu Sheng Zhang Hao Qiu Zhi-Qiang Xie Wei-Feng Tang Yu Chen Xi Wei 

机构地区：[1]Department of General Surgery,Changzhou Third People’s Hospital,Changzhou 213001,Jiangsu Province,China [2]Laboratory Medicine,School of Medicine,Jiangsu University,Zhenjiang 212000,Jiangsu Province,China [3]Department of Clinical Laboratory,Fujian Medical University Union Hospital,Fuzhou 350001,Fujian Province,China [4]Department of Cardiothoracic Surgery,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210000,Jiangsu Province,China [5]Department of Medical Oncology,Fujian Cancer Hospital and Fujian Medical University Cancer Hospital,Fuqing 350014,Fujian Province,China [6]Department of Pathology,Affiliated People’s Hospital of Jiangsu University,Zhenjiang 212002,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第4期67-80,共14页世界胃肠肿瘤学杂志(英文)

基　　金：Supported by the Major Project of Changzhou Science and Technology Bureau,No.CJ20220255.

摘　　要：BACKGROUND Accumulating studies indicated that maintain nuclei homeostasis was deemed to the protective factors for the occurrence of cancer.Thus,high-mobility group box 1(HMGB1)might influence the risk and poorer prognoses of colorectal cancer(CRC).AIM This study was designed to investigate whether HMGB1 polymorphisms influence the risk and lymph node metastasis(LNM)of CRC.METHODS Firstly,we designed an investigation with 1003 CRC patients and 1303 cancer-free controls to observe whether HMGB1 rs1412125 T>C and rs1045411 C>T SNPs could influence the risk of cancer.Subsequently,we carried out a correlation-analysis to assess whether these SNPs could alter the risk of LNM.RESULTS The current investigation suggested a relationship of HMGB1 rs1412125 SNP with the increased susceptibility of CRC.In a subgroup analysis,our findings suggested that this SNP could enhance an occurrence of CRC in≥61 years,non-drinker and body mass index<24 kg/m2 subgroups.However,we found that there was null association between HMGB1 rs1412125 SNP and LNM,even in different CRC region.These observations were confirmed by calculating the power value(more than 0.8).The association of HMGB1 rs1045411 C>T SNP with CRC risk and LNM was not found in any compare.CONCLUSION This study highlights a possible association between HMGB1 rs1412125 polymorphism and the increased risk of CRC.In the future,more studies should be conducted to explore HMGB1 rs1412125 polymorphism in relation to CRC development.

关 键 词：High-mobility group box 1 Colorectal cancer POLYMORPHISM Immune Lymph nodes metastasis 

分 类 号：R73[医药卫生—肿瘤]