Factors associated with false fecal immunochemical test results in colorectal cancer screening  

作　　者：Shu-Yuan Wang Xue-Tao Dong Zhen Yuan Lei-Xin Jin Wei-Feng Gao You-Kui Han Ke-Min Ni Zhao-Ce Liu Jun-Ying Wang Xiao-Meng Wei Xiao-Min Su Xi Peng Chun-Ze Zhang 

机构地区：[1]School of Medicine,Nankai University,Tianjin 300071,China [2]Department of Gastroenterology,Tianjin Union Medical Center,Tianjin 300121,China [3]School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [4]Department of Colorectal Surgery,Tianjin Union Medical Center,Tianjin 300121,China [5]Department of General Surgery,Tianjin Union Medical Center,Tianjin 300121,China [6]Hospital Infection Management Division,Tianjin Union Medical Center,Tianjin 300121,China

出　　处：《World Journal of Gastrointestinal Oncology》2025年第4期131-143,共13页世界胃肠肿瘤学杂志(英文)

基　　金：Supported by Natural Science Foundation of Tianjin,No.21JCZDJC00060 and No.21JCYBJC00180;Tianjin Health and Medical Science and Technology Project,No.TJWJ2023QN040;National Key Research and Development Program,No.2017YFC1700606 and No.2017YFC1700604.

摘　　要：BACKGROUND Certain subgroups are at an increased risk of false fecal immunochemical test(FIT)results;however,related studies are limited,and the available evidence is conflicting.AIM To evaluate factors associated with false-positive and false-negative FIT results.METHODS This retrospective study was based on the database of the Tianjin Colorectal Cancer Screening Program from 2012 to 2020.A total of 4129947 residents aged 40-74 years completed at least one FIT.Of these,24890 asymptomatic participants who underwent colonoscopy examinations and completed lifestyle questionnaires were included in the analysis.Multivariable logistic regression was performed to identify the factors associated with false FIT results.RESULTS Among the overall screening population,88687(2.15%)participants tested positive for FIT.The sensitivity,specificity,positive predictive value,and negative predictive value of FIT for advanced neoplasms were 58.2%,44.8%,9.7%,and 91.3%,respectively.Older age,female sex,smoking,alcohol consumption,higher body mass index,and hemorrhoids were significantly associated with increased odds of false-positive and lower odds of falsenegative FIT results.Moreover,features of high-grade dysplasia or villous for advanced adenoma and the presence of cancer were also associated with lower odds of false-negative results,while irregular exercise and diverticulum were associated with higher odds of false-positive results.CONCLUSION FIT results may be inaccurate in certain subgroups.Our results provide important evidence for further individualization of screening strategies.

关 键 词：Fecal immunochemical test Advanced colorectal neoplasm False positive False negative Colorectal cancer screening 

分 类 号：R73[医药卫生—肿瘤]