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作 者:郭翠霞[1] 孙丽娟[1] 刘妍[2] 张铁娟[1] 王莉[1] 韩吉晶[1] 吴青青[1] GUO Cuixia;SUN Lijuan;LIU Yan;ZHANG Tiejuan;WANG Li;HAN Jijing;WU Qingqing(Department of Ultrasound,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Hospital,Beijing 100026,China;Prenatal Diagnosis Center,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing Maternal and Child Health Hospital,Beijing 100026,China)
机构地区:[1]首都医科大学附属北京妇产医院、北京妇幼保健院超声科,北京100026 [2]首都医科大学附属北京妇产医院、北京妇幼保健院产前诊断中心,北京100026
出 处:《中国医学影像技术》2025年第3期363-367,共5页Chinese Journal of Medical Imaging Technology
基 金:北京市医院管理中心培育计划(PX2024052);北京市自然科学基金(7222063);高层次公共卫生技术人才建设项目(学科骨干-02-06)。
摘 要:目的观察胎儿脑皮质发育畸形(MCD)产前超声表现。方法回顾性分析经胎儿颅脑MRI和/或遗传学检查确诊MCD的37胎单胎胎儿,观察其产前超声表现。结果37胎中,大脑外侧裂异常29胎(29/37,78.38%),侧脑室增宽/不对称26胎(26/37,70.27%),大脑表面沟回异常22胎(22/37,59.46%),透明隔腔(CSP)/胼胝体(CC)异常14胎(14/37,37.84%),脑中线偏移/弯曲11胎(11/37,29.73%),蛛网膜下腔增宽11胎(11/37,29.73%),头围<均值2个标准差10胎(10/37,27.03%),小脑半球/蚓部异常9胎(9/37,24.32%),脑实质内异常回声7胎(7/37,18.92%),脑中线囊肿7胎(7/37,18.92%),神经节隆起增大2胎(2/37,5.41%)。结论胎儿MCD产前超声主要表现为大脑外侧裂形态异常、侧脑室增宽/不对称及大脑表面沟回异常,可伴CSP/CC异常、脑中线偏移/弯曲、蛛网膜下腔增宽及头围异常。Objective To observe prenatal ultrasonic findings of fetal malformation of cortical development(MCD).Methods Totally 37 singleton fetuses with MCD diagnosed by fetal cranial MRI and/or genetic examination were retrospectively enrolled,and prenatal ultrasonic manifestations were observed.Results Among 37 fetuses,29(29/37,78.38%)were found with abnormal Sylvian fissure,26(26/37,70.27%)with widened/asymmetrical lateral ventricles,22(22/37,59.46%)with abnormal surface sulci,14(14/37,37.84%)with abnormal cavity of septum pellucidum(CSP)/corpus callosum(CC),11(11/37,29.73%)with midline deviation/curvature,11(11/37,29.73%)with widened subarachnoid space,10(10/37,27.03%)with head circumference<2 standard deviation below mean value,9(9/37,24.32%)with abnormalities in the cerebellar hemisphere/vermis,7(7/37,18.92%)with abnormal echoes in the brain parenchyma,7(7/37,18.92%)with midline cysts and 2(2/37,5.41%)with enlarged ganglion eminence.Conclusion Fetal MCD mainly presented as abnormal Sylvian fissure,widened/asymmetrical lateral ventricles and abnormal surface sulci,which might accompanied by abnormal CSP/CC,midline deviation/curvature,widened subarachnoid space and abnormal head circumference in prenatal ultrasound.
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