微波消融离体猪肺血管热沉效应的影响因素  

Impact factors of vascular heat sink effect during in vitro microwave ablation of porcine lung

作　　者：陈泽南 张忠亮 王思斌 郭新垣 张晶 张啸波 何晓锋 孟亮亮 张欣 魏颖恬 肖越勇 南群[4] 张肖 CHEN Zenan;ZHANG Zhongliang;WANG Sibin;GUO Xinyuan;ZHANG Jing;ZHANG Xiaobo;HE Xiaofeng;MENG Liangliang;ZHANG Xin;WEI Yingtian;XIAO Yueyong;NAN Qun;ZHANG Xiao(Graduate School,Chinese PLA Medical School,Beijing 100853,China;Department of Radiology,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Medical Imaging,Chinese PAP Force Hospital of Beijing,Beijing 100600,China;College of Chemistry and Life Science,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]中国人民解放军医学院研究生院,北京100853 [2]中国人民解放军总医院第一医学中心放射诊断科,北京100853 [3]武警北京市总队医院医学影像科,北京100600 [4]北京工业大学化学与生命科学院,北京100124

出　　处：《中国医学影像技术》2025年第3期383-388,共6页Chinese Journal of Medical Imaging Technology

基　　金：军队保健项目基金(22BJZ18)。

摘　　要：目的观察微波消融(MWA)离体猪肺血管热沉效应的影响因素。方法针对离体猪肺组织块利用气泵等压充气、玻璃管与蠕动泵循环灌注鸭血等建立体外模拟模型,于8种不同组合条件下(血管直径3或5 mm、血流灌注30或50 cm/s及血管与消融天线距离5或10 mm)行MWA,每种重复3次;记录消融中血管侧最高温度T V、对照侧最高温度T C,以及完成后血管侧消融深度D V及对照侧消融深度D C;基于模拟血管直径、血流灌注及其与消融天线的距离构建多因素线性回归方程,分别观察|T C-T V|及|D C-D V|的影响因素。结果模拟血管直径与|T C-T V|及|D C-D V|均呈线性正相关(P均<0.001);模拟血管与消融天线距离与|T C-T V|及|D C-D V|均呈线性负相关(P均<0.001),尤其后者对血管热沉效应的影响更为显著;模拟血液流速与|T C-T V|及|D C-D V|均无明显线性相关(P均>0.05)。结论模拟血管直径及血管与消融天线距离均为MWA离体猪肺热沉效应的影响因素且后者更为显著,而模拟血液流速对此则无明显影响。Objective To observe the impact factors of vascular heat sink effect during in vitro microwave ablation(MWA)of porcine lung.Methods Simulation models were established using in vitro porcine lung tissue blocks based on isobaric inflation with an air pump and cyclic perfusion of duck blood with a glass tube and peristaltic pump,etc.MWA was performed under 8 different combining conditions(vessel diameter of 3 or 5 mm,blood perfusion of 30 or 50 cm/s,as well as distance between vessel and ablation antenna of 5 or 10 mm)each for 3 times.The highest temperature T V on vessel side and T C on control side during MWA,and ablation depth D V on vessel side and D C on control side after MWA were recorded.Multi-factor linear regression equations were constructed based on simulated vessel diameters,blood perfusion and distance between vessel and ablation antenna,and the impact factors of|T C-T V|and|D C-D V|were screened,respectively.Results Simulated vessel diameter showed linear positive correlation with both|T C-T V|and|D C-D V|(both P<0.001).Simulated distance between vessel and ablation antenna showed linear negative correlation with both|T C-T V|and|D C-D V|(both P<0.001),and the latter had more obvious impact on vascular heat sink effect than the former.Meanwhile,no significant linear relationship was found between simulated blood perfusion and|T C-T V|nor|D C-D V|(both P>0.05).Conclusion Simulated vessel diameter and distance between vessel and ablation antenna were both impact factors of vascular heat sink effect during in vitro MWA of porcine lung,and the latter was more influential,whereas simulated blood perfusion showed no significant impact on it.

关 键 词：动物实验 猪 肺 血管 消融技术 热沉效应 

分 类 号：R-33[医药卫生] R815