不同分期帕金森病脑网络动态功能连接改变  

Dynamic functional connectivity changes of brain networks in different stages of Parkinson disease

作　　者：刘沁茹 唐玉清 谭长连[1] 李旭 牛亚平 黄聪丽 廖海燕[1] LIU Qinru;TANG Yuqing;TAN Changlian;LI Xu;NIU Yaping;HUANG Congli;LIAO Haiyan(Department of Radiology,the Second Xiangya Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院放射科,湖南长沙410011

出　　处：《中国医学影像技术》2025年第3期389-393,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划(2022YFC2009900);湖南省自然科学基金(2022JJ30818);长沙市自然科学基金(kq2202416);湖南省临床医疗技术创新引导项目(2021SK53502)。

摘　　要：目的观察不同分期帕金森病(PD)脑网络动态功能连接(dFC)改变。方法前瞻性对52例早期PD(早期PD组)、36例晚期PD(晚期PD组)及38名健康对照(HC组)行静息态功能MRI;以滑动窗口法、独立成分分析及k均值聚类等方法获取脑网络dFC强度及时间属性(包括分数窗口、停留时间及转换次数)。结果PD患者视觉网络(VIS)、感觉运动网络(SMN)、默认模式网络(DMN)、小脑网络(CB)及认知执行网络(CEN)的网络内及网络间连接模式均发生改变。共获得4种dFC状态,状态Ⅰ、Ⅱ下成分间连接较强,而状态Ⅲ、Ⅳ下连接较弱。晚期PD组、早期PD组及HC组分数窗口及停留时间在状态Ⅱ下依次升高,而在状态Ⅲ下依次降低(P均<0.05)。状态Ⅰ、Ⅳ下,早期PD组与晚期PD组分数窗口及停留时间差异均无统计学意义(P均>0.05),且状态Ⅰ下分数窗口及停留时间均低于HC组(P均<0.05)、状态Ⅳ下分数窗口均高于HC组(P均<0.05)。结论PD dFC时间属性发生改变,具有更高分离状态;分数窗口及停留时间与PD分期相关,有望成为评估PD分期的新型生物学指标。Objective To observe changes of dynamic functional connectivity(dFC)of brain networks in different stages of Parkinson disease(PD).Methods Totally 52 early-stage PD patients(early PD group),36 late-stage PD patients(late PD group)and 38 healthy controls(HC group)were prospectively enrolled,and resting-state functional MRI were performed.The sliding window,independent component analysis and k-means clustering were used to extract dFC intensity and temporal properties,including fractional windows,dwell time and transition frequency.Results Network connectivity patterns within and between visual network(VIS),sensorimotor network(SMN),default mode network(DMN),cerebellar network(CB)and cognitive executive network(CEN)were altered in PD patients.Four dFC states were identified,in which connections between components in statesⅠandⅡwere compact,while in statesⅢandⅣwere sparse.The fractional window and dwell time of late PD group,early PD group and HC group successively increased under stateⅡ,but successively decreased under stateⅢ(all P<0.05).Under stateⅠandⅣ,no significant difference of fractional window nor dwell time was found between early PD group and late PD group(both P>0.05),and the above indexes under stateⅠwere both lower than those in HC group(all P<0.05),the fraction window under stateⅣwas higher than that in HC group(both P<0.05).Conclusion The temporal properties of dFC in PD patients were altered,characterized by increased tendency toward segregated states.Furthermore,fractional windows and dwell time were associated with PD disease stages,suggesting that dFC parameters might serve as novel biomarkers for assessing clinical progression of PD.

关 键 词：帕金森病 脑 磁共振成像 功能连接 前瞻性研究 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]